Gut Microbiota Dysbiosis and Translocation During IBD and Parkinson

Gut Microbiota Dysbiosis and Translocation Within Patients Suffering From Diseases Associated With Increased Intestinal Barrier Permeability : IBD and Parkinson

Inflammatory bowel diseases (IBD) and Parkinson disease (PD) are complex and multifactorial pathologies. Gut microbiota seems to play an active role. Indeed the digestive microbiota of patients with IBD or PD exhibits different compositions compared with asymptomatic subjects.

Bacterial translocation from gut to blood has been reported.

The investigators designed a case-control study to investigate the digestive microbiota and bacterial translocation during IBD and PD. The investigators want to evaluate gut microbiota bacteria involved in dysbiosis and bacterial translocation during IBD and PD. The investigators want to identify bacterial populations that can serve as biomarkers for clinical practice.

Inclusion Criteria:

• PD patients : age < or = 60 years
• asymptomatic subjects : no chronic disease
• asymptomatic subjects : no treatment

Exclusion Criteria:

• severe anemia (Hb<7g/L)
• people who don't read french
• pregnant women
• people treated by antibiotic, probiotic or prebiotic during the 2 month before inclusion
• people with any diagnosed or treated pathology