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| Name | Class |
|---|---|
| Hvidovre University Hospital | OTHER |
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This study will examine the role of the colon as an endocrine organ with a focus on the secretion of gastrointestinal peptides.
This study will examine the role of the colon as an endocrine organ with a focus on the secretion of gastrointestinal peptides.
We aim to determine the contribution of the colon to the fasting and postprandial release of gut peptides such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Young healthy men will be examined on three occasions at a clinical research Facility after an overnight fast. On one occasion the colon will also be emptied using a cathartic (picoprep). On two occasions an oral solution of lactulose will be administered to stimulate fermentation by colonic bacteria.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Day A | Experimental | After an overnight fast participants will receive an oral solution of lactulose (20g lactulose/200mL water). |
|
| Day B | Experimental | After an overnight fast participants will drink 200mL of water |
|
| Day C | Experimental | After an overnight fast and an evacuation of the colonic content, participants will receive an oral solution of lactulose (20g lactulose/200mL water). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lactulose | Other | Oral solution lactulose (20g lactulose/200mL water). |
| |
| Measure | Description | Time Frame |
|---|---|---|
| GLP-1 | Plasma concentrations of glucagon-like peptide-1 (GLP-1) | -60, -45, -30, -15, 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210, 225, 240, 255, 270. 285, 300 min |
| Measure | Description | Time Frame |
|---|---|---|
| PYY | Plasma concentrations of peptide YY (PYY) | -60, -45, -30, -15, 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210, 225, 240, 255, 270. 285, 300 min |
| Hydrogen breath test | Concentrations of hydrogen in exhaled air |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jens J Holst, MD, Dr.med. | University of Copenhagen | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Copenhagen | Copenhagen | Capital | 2200 | Denmark | ||
| Hvidovre University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34508600 | Derived | Christiansen CB, Veedfald S, Hartmann B, Gauguin AM, Moller S, Moritz T, Madsbad S, Holst JJ. Colonic Lactulose Fermentation Has No Impact on Glucagon-like Peptide-1 and Peptide-YY Secretion in Healthy Young Men. J Clin Endocrinol Metab. 2022 Jan 1;107(1):77-87. doi: 10.1210/clinem/dgab666. |
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| ID | Term |
|---|---|
| D007792 | Lactulose |
| C005701 | picosulfate sodium |
| D014867 | Water |
| ID | Term |
|---|---|
| D004187 | Disaccharides |
| D009844 | Oligosaccharides |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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Healthy men studied on three occasions. Study A and B will be conducted in random order. Day C wil always be conducted as the last study day.
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| Picoprep |
| Other |
Cathartic to accomplish an evacuation of the colonic content. |
|
| Placebo (water) | Other | oral administration of Water (200mL). |
|
| -60, -45, -30, -15, 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210, 225, 240, 255, 270. 285, 300 min |
| Ghrelin | Plasma concentrations of ghrelin | -60, -45, -30, -15, 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210, 225, 240, 255, 270. 285, 300 min |
| Motilin | Plasma concentrations of motilin | -60, -45, -30, -15, 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210, 225, 240, 255, 270. 285, 300 min |
| Neurotensin | Plasma concentrations of Neurotensin | -60, -45, -30, -15, 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210, 225, 240, 255, 270. 285, 300 min |
| Glucagon | Plasma concentrations of glucagon | -60, -45, -30, -15, 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165, 180, 195, 210, 225, 240, 255, 270. 285, 300 min |
| Hvidovre |
| Capital |
| 2650 |
| Denmark |
| D000073893 |
| Sugars |
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |