Effect of an Exercise on Serum Uncoupling Protein-1 Level and the Role of Uncoupling Protein-1-3826 A/G Polymorphism

The Effect of an Acute Maximal Exercise on Serum Uncoupling Protein-1 Level and the Role of Uncoupling Protein-1-3826 A/G Polymorphism

This study aims to determine the effect of an acute maximal exercise on serum uncoupling protein-1, irisin, interleukin 6 levels, and on blood lipid and lipoprotein concentrations. This study also evaluates the role of uncoupling protein-1-3826 A/G polymorphism on this eventual effect.

Therefore, this study hypothesizes that:

H01: Sedentary people and athletes' serum uncoupling protein 1, irisin, and interleukine 6 levels are different before and after an acute maximal exercise.

H02: Sedentary people and athletes' basal serum uncoupling protein 1 levels are associated with uncoupling protein 1-3826 A/G polymorphism.

H03: Uncoupling protein 1-3826 A/G polymorphism has a modifying role in the effect of maximal exercise on serum uncoupling protein 1 levels.

H04: Sedentary people and athletes' basal serum lipid and lipoprotein levels are associated with uncoupling protein 1-3826 A/G polymorphism.

H05: Uncoupling protein 1-3826 A / G polymorphism has a modifying role in the effect of maximal exercise on serum lipid and lipoprotein levels.

Inclusion Criteria:

• Athletes group:

  • Must be basketball, or volleyball, or handball players.
  • Must be subjects who have been training regularly for at least 3 months.

• Sedentary group:

  * Must be subjects who have not been training regularly for at least 3 months.

• For both groups:

  • Healthy.
  • Non obese (body mass index < 30).
  • Aged between 18 and 35 years.

Exclusion Criteria:

• For both groups:

  • Being regular consumer of cigarettes, alcohol, drugs and antioxidant substances.
  • Being obese (body mass index > 30).
  • Having an acute or chronic injury which is limiting physical performance.
  • Having a disease (anemia, infection...) detected from the biochemical analysis of the blood samples.
  • Being injured or sick during the study.