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This study is to determine the effectiveness of a computerized clinical decision support tool (Best Practice Alert - BPA) in reducing unnecessary platelet transfusions based on guidelines published by national transfusion societies such as the AABB (formerly American Association of Blood Banks).
A computerized alert will be deployed through the electronic health record. The alert will trigger when a provider orders platelet transfusion above a threshold supported by current guidelines. The alert will provide information on current evidence and give the provider the option to cancel the order or proceed. The alert will not be triggered in procedural areas such as the operating room or as part of any emergency orders to prevent any delays to urgent patient care.
The proposed project will evaluate this alert by randomizing its implementation by patient chart. The investigators will observe the prevalence of this alert and its impact on ordering practices for the next 3 months. For patient charts randomized not to receive the intervention, the providers will not receive any alerts, but the analytics tool will record if the alert would have been triggered and the pertinent clinical information. After a period of three months, the investigators will review patient and provider information through analytics tools, assessing differences in platelet usage between the patients whose charts showed the alerts vs. those (control) patient charts not showing alerts.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Best Practice Alert | Experimental | Platelet transfusion orders for patients with a recent platelet count exceeding 50,000 per microliter (50k/uL) will trigger an alert in the electronic health record that displays current guidelines for platelet transfusion. The alert will allow providers to bypass the recommendation and continue with platelet ordering by selecting a clinical acknowledgement / exception to recommendation.Exclusions will be built into the alert to avoid triggering in operative or procedural settings, for neurosurgery providers, or patients on anti-platelet medications. |
|
| No Best Practice Alert | No Intervention | For this group, no visible best practice alert will activate in the electronic health record for platelet transfusion orders and recent counts above 50k/uL. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Computer electronic health record alert (Best Practice Alert - BPA) | Other | Upon ordering platelets in patients with recent platelet count >50,000, a pop-up within the electronic health system will recommend to not continue with transfuse product order and provide clinical exceptions to continue. Importantly, the alert does not trigger in operating areas, emergency medicine treatment areas, for certain specialties like neurosurgery or for massive transfusion orders. |
| Measure | Description | Time Frame |
|---|---|---|
| Platelet transfusions above threshold | Number of platelet transfusions occurring in patients with recent platelet counts above 50k/uL | Data will be initially reviewed before 6 months from start with anticipated completion 1 year from start |
| Measure | Description | Time Frame |
|---|---|---|
| Total platelet transfusions | Total number of platelet transfusions occurring during study period. | Data will be initially reviewed before 6 months from start with anticipated completion 1 year from start |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Colin H Murphy, MD | Stanford University | Principal Investigator |
| Neil Shah, MD | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford Healthcare | Stanford | California | 94305-5626 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34081800 | Result | Murphy C, Mou E, Pang E, Shieh L, Hom J, Shah N. A randomized study of a best practice alert for platelet transfusions. Vox Sang. 2022 Jan;117(1):87-93. doi: 10.1111/vox.13132. Epub 2021 Jun 3. |
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| ID | Term |
|---|---|
| D013921 | Thrombocytopenia |
| ID | Term |
|---|---|
| D001791 | Blood Platelet Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D000095542 | Cytopenia |
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