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All encountered cases with POI will be assessed and examined then investigated. Eligible cases will be included in the study
Patients will be subjected to injection of autologous PRP inside the ovary about 0.5-1 mml by laparoscopy
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PRP injection | Experimental | injection of PRP inside ovary by the assistance of laparoscopy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PRP injection inside the ovary by laparoscoy. The injection volume is 2 ml | Procedure | intraovarian injection of 2 mml of PRP by laparoscopic guide |
|
| Measure | Description | Time Frame |
|---|---|---|
| Resumption of ovarian hormonal function | Measurement of Estradiol level on Day 3 of cycle | 3-6 months |
| Resumption of ovarian folliclugenesis | Assessment of the presence of oocytes by trans vaginal ultrasound on day 3 | 3-6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Resumption of menstruation | Occurrence of Menstruation after secondary amenrorrhea by questionnaire | 3-6 months |
| Fertility potential | Potential to get pregnant after ICSI procedure |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Adel Elgergawy | Tanta | Egypt |
we will decide later
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| ID | Term |
|---|---|
| D016649 | Primary Ovarian Insufficiency |
| D007246 | Infertility |
| ID | Term |
|---|---|
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
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All eligible patient will recieve the treatment with PRP
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| 3-6 months |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |