Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
In emergency medicine, acute pain is a common reason for consultation. It is recommended that patients in moderate to severe pain should receive a combination of intravenous acetaminophen and morphine. However, the data are sparse to support this strategy. Thus, the purpose of our research is to test non-inferiority of IV morphine alone versus IV acetaminophen and morphine in a multicenter, randomized, controlled double blind trial in ED patients with moderate to severe acute pain.
This study is designed to assess whether IV morphine alone is non inferior to combination IV acetaminophen and morphine for the management of moderate to severe pain in the ED. Numeric rating scale pain score will be compared between those who receive morphine alone and who will receive acetaminophen and morphine at 15, 30, 45 and 60 min post first injection.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment group | Experimental | Morphine IV and the placebo of acetaminophen IV. |
|
| Control group | Active Comparator | Morphine IV and acetaminophen IV |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| placebo of acetaminophen IV | Drug | Mophine IV: Initial loading dose of 0.1 mg/kg (ensuring that the maximum dose of 10 mg is not exceeded) followed by bolus of 0.05 mg/kg every 10 minutes (taking care not to exceed the maximum dose of 5 mg) as reported by the recommandation of experts of the french society of urgency care. Placebo of acetaminophen IV: Sodium chloride 0.9% |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of numeric rating scale pain scores between those who received morphine alone and who received combination of acetaminophen and morphine at 30 minutes. | The Numerical Pain Rating Scale measures the perception of pain intensity with an eleven-point numerical scale. The scale is composed of 0 (no pain at all) to 10 (worst imaginable pain). | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of numeric rating scale pain scores between those who received morphine alone and who received the combination of acetaminophen and morphine at 10min, 20 min, 45 min and 60min. | The Numerical Pain Rating Scale measures the perception of pain intensity with an eleven-point numerical scale. The scale is composed of 0 (no pain at all) to 10 (worst imaginable pain). | 60 minutes |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Céline LONGO, Doctor | Nantes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Angers University Hospital | Angers | 49100 | France | |||
| Bordeaux University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41733913 | Derived | Cattin G, Viglino D, Segard J, Volteau C, Chauvin A, Galinski M, Maigre O, Delamare-Fauvel A, Le Pottier M, Debierre V, Chouihed T, Longo C, Jenvrin J, Freund Y, Montassier E. Morphine Plus Placebo vs Morphine Plus Acetaminophen for Acute Pain in the Emergency Department: A Randomized Clinical Trial. JAMA Netw Open. 2026 Feb 2;9(2):e2560250. doi: 10.1001/jamanetworkopen.2025.60250. | |
| 36522767 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
double blind
|
| acetaminophen IV | Drug | Mophine IV: Initial loading dose of 0.1 mg/kg (ensuring that the maximum dose of 10 mg is not exceeded) followed by bolus of 0.05 mg/kg every 10 minutes ((taking care not to exceed the maximum dose of 5 mg) as reported by the recommandation of experts of the french society of urgency care. Acetaminophen IV: 1 g |
|
| Estimated cumulative dose of morphine in both arms at a dose -by-weight (mg/kg) dose during the first 30 minutes | 30 minutes |
| Frequency and intensity of adverse reactions: nausea, vomiting, respiratory failure, hypotension | through study completion, an average of 60 minutes |
| Bordeaux |
| 33000 |
| France |
| Châteaubriant Hôspital | Châteaubriant | 44146 | France |
| Grenoble University Hospital | Grenoble | 38700 | France |
| La Roche-sur-Yon Hospital | La Roche-sur-Yon | 85925 | France |
| Nancy University Hospital | Nancy | 54035 | France |
| Nantes University Hospital | Nantes | 44093 | France |
| Lariboisière University Hospital - APHP | Paris | 75010 | France |
| La Pitié-Salpêtrière University Hospital | Paris | 75013 | France |
| ROUEN University hospital | Rouen | 76000 | France |
| CH Saint Nazaire | Saint-Nazaire | 44 | France |
| Derived |
| Cattin G, Jenvrin J, Hardouin JB, Longo C, Montassier E. Intravenous acetaminophen with morphine versus intravenous morphine alone for acute pain in the emergency room: protocol for a multicenter, randomized, placebo-controlled, double-blinded study (ADAMOPA). Trials. 2022 Dec 15;23(1):1016. doi: 10.1186/s13063-022-06943-0. |
| ID | Term |
|---|---|
| D000377 | Agnosia |
| D059787 | Acute Pain |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
Not provided
Not provided