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Principal Investigator left lab before study start
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This study investigates the effects of two hormones called epinephrine and cortisol on how the brain processes emotional material using functional MRI to measure brain activity. The study hopes to learn how epinephrine and cortisol affect the brain differently in depressed and non-depressed individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Arm, CORT + EPI, then PLB + EPI | Active Comparator | Healthy participant will receive cortisol pill and epinephrine infusion |
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| Healthy Arm, PLB + EPI, then CORT + EPI | Active Comparator | Healthy participant will receive placebo pill and epinephrine infusion |
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| Depression Arm, CORT + EPI, then PLB + EPI | Experimental | Depressed participant will receive cortisol pill and epinephrine infusion |
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| Depression Arm, PLB + EPI, then CORT + EPI | Experimental | Depressed participant will receive placebo pill and epinephrine infusion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hydrocortisone Acetate (CORT) | Drug | Participants will receive a single dose of hydrocortisone at a dosage of 0.65 mg/kg |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sadness-induced subgenual cingulate activity as measured by functional magnetic resonance imaging | 2 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Keith Sudheimer, Ph.D. | Stanford University | Principal Investigator |
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| ID | Term |
|---|---|
| D003863 | Depression |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| C021650 | hydrocortisone acetate |
| D006854 | Hydrocortisone |
| C036526 | epinephrine sulfate |
| D004837 | Epinephrine |
| ID | Term |
|---|---|
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
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| Epinephrine Sulfate (EPI) | Drug | Participants will receive a continuous infusion of epinephrine at a dosage of 80 ng/kg/min |
|
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| Placebo (PLB) | Drug | Participants will receive a placebo |
|
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D015062 | 11-Hydroxycorticosteroids |
| D006889 | Hydroxycorticosteroids |
| D000305 | Adrenal Cortex Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D015065 | 17-Hydroxycorticosteroids |
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D000588 | Amines |
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D002395 | Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |