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Sleeping under hypoxic conditions can impair cognition and autonomic nervous activity. A short daytime nap can modify these changes. Here we propose a randomized, cross-over study to evaluate the heart rate variability during a 90 min nap in a normobaric hypoxic chamber. In addition, we will investigate sleep architecture, vigilance, attention and memory.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normoxia | Placebo Comparator | 20.9% oxygen |
|
| Hypoxia 1 | Active Comparator | 15.0% oxygen |
|
| Hypoxia 2 | Active Comparator | 12.8% oxygen |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normoxia | Other | Nap in hypoxia chamber at 20.9% oxygen (36 m asl) |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate variability | Mean RR interval measured by polysomnography (ms) | During 90 minutes nap under normoxic (20.9%) vs. 12.8% hypoxic condition |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate variability | Mean RR interval measured by polysomnography (ms) | During 90 minutes nap under normoxic (20.9%) vs. 15.0% hypoxic condition |
| Sleep Efficiency (SE) | Measured by continuous polysomnography (min) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anja Mähler, PhD | Charite University, Berlin, Germany | Principal Investigator |
| Alain Riveros, MD | Charite University, Berlin, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Experimental & Clinical Research Center | Berlin | 13125 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35685284 | Result | Riveros-Rivera A, Penzel T, Gunga HC, Opatz O, Paul F, Klug L, Boschmann M, Mahler A. Hypoxia Differentially Affects Healthy Men and Women During a Daytime Nap With a Dose-Response Relationship: a Randomized, Cross-Over Pilot Study. Front Physiol. 2022 May 24;13:899636. doi: 10.3389/fphys.2022.899636. eCollection 2022. |
| Label | URL |
|---|---|
| Results publication | View source |
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Individual participant data that underlie the results of reported articles (text, tables, figures, supplemental data) will be shared after deidentification.
Beginning 9 months and ending 36 months following article publication.
Researchers who provide a methodologically sound proposal.
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| ID | Term |
|---|---|
| D000860 | Hypoxia |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Hypoxia 1 |
| Other |
Nap in hypoxia chamber at 15.0% oxygen (simulates 2660 m asl) |
|
| Hypoxia 2 | Other | Nap in hypoxia chamber at 12.8% oxygen (simulates 4000 m asl) |
|
| During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Wake After Sleep Onset (WASO) | Measured by continuous polysomnography (min) | During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Sleep Onset Latency (SOL) | Measured by continuous polysomnography (min) | During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Low Frequency / High Frequency Band | Mean LF/HF ratio measured by continuous ECG | During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Standard Deviation 1 / Standard Deviation 2 | Mean SD1/SD2 ratio measured by continuous ECG | During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| RR intervals longer than 50 ms | Percentage pNN50 measured by continuous ECG (%) | During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Core Body Temperature | Mean temperature measured by continuous double sensor monitoring (°C) | During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Skin Temperature | Mean temperature measured by continuous double sensor monitoring (°C) | During 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Digit Span Task | Longest memorized digit series (n, normal range 5-9, higher is better) | After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Psychomotor Vigilance Task Subscale 1 | Number of lapses (normal range 0-6, higher is worse) | After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Psychomotor Vigilance Task Subscale 2 | Mean reaction time (normal range 100-500 ms, higher is worse) | After 90 min nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Color Stroope Task Subscale 1 | Number of incongruency errors (normal range 0-5, higher is worse) | After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Color Stroope Task Subscale 2 | Congruent response time (normal range 400-500 ms, higher is worse) | After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Color Stroope Task Subscale 3 | Incongruent response time (normal range 600-800 ms, higher is worse) | After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Color Stroope Task Subscale 4 | Congruent accuracy (above 95% is normal, higher is better) | After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |
| Color Stroope Task Subscale 5 | Incongruent accuracy (above 85% is normal, higher is better) | After 90 minutes nap under normoxic (20.9%) vs. two hypoxic conditions (12.8 and 15%) |