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"MEtabolomics and MicrObiomics in caRdIovAscular diseases Mannheim (MEMORIAM) " is a single-center, prospective and observational study investigating to identify disease-specific metabolic, respectively microbiomic, patterns of patients with high-risk cardiovascular diseases. High-risk cardiovascular diseases comprise patients suffering from acute heart failure (AHF), ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), sepsis, septic shock, ischemic and non-ischemic cardiomyopathy.
Scientific evidence about the metabolomic and microbiomic changes in high-risk cardiovascular patients is still lacking.
The acute, critical or progressive disease status predestinies to relevant changes in cardiovascular metobolism. High-risk patients in the present trial comprise those with acute heart failure, myocardial infarction (STEMI and NSTEMI), sepsis, septic shock, ischemic and non-ischemic cardiomyopathy with severely reduced left ventricular ejection fraction (LVEF <35%).
Therfore this study investigates to identify disease-specific patterns of metabolic and microbiomic changes. These patterns may help to understand pathophysiology at the metabolic stages and find out those patients being at highest risk of adverse future outcome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute heart failure | All consecutive patients admitted with acute heart failure to University Medical Center Mannheim. One venous blood withdraw will be performed. Demographic and clinical data will be documented. |
| |
| STEMI | All consecutive patients admitted with STEMI to University Medical Center Mannheim. One venous blood withdraw will be performed. Demographic and clinical data will be documented. |
| |
| NSTEMI | All consecutive patients admitted with NSTEMI to University Medical Center Mannheim. One venous blood withdraw will be performed. Demographic and clinical data will be documented. |
| |
| Ischemic cardiomyopathy | All consecutive patients with an implantable cardioverter defibrillator (ICD) due to ischemic cardiomyopathy and LVEF <35% presenting for ICD check-up to University Medical Center Mannheim. One venous blood withdraw will be performed. Demographic and clinical data will be documented. |
| |
| Non-ischemic cardiomyopathy | All consecutive patients with an implantable cardioverter defibrillator (ICD) due to non-ischemic cardiomyopathy and LVEF <35% presenting for ICD check-up to University Medical Center Mannheim. One venous blood withdraw will be performed. Demographic and clinical data will be documented. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood draw | Other | venous blood withdraw (ca. 40ml) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Disease-specific metabolic/microbiomic biomarker patterns. | Expression of disease-specific metabolic/microbiomic biomarker patterns at the time of acute disease presentation | Within 24h after disease onset |
| Measure | Description | Time Frame |
|---|---|---|
| All-cause and cardiovascular mortality. | All-cause and cardiovascular mortality, at 6 months and 12 months | 12 months after inclusion |
| Cardiac rehospitalization. | Cardiac rehospitalization, at 6 months and 12 months. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients suffering from acute cardiovascular diseases such as acute heart failure, STEMI, NSTEMI, ischemic and dilative cardiomyopathies and sepsis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michael Behnes, PD Dr. | Contact | 0049 621 383 6239 | michael.behnes@umm.de | |
| Ibrahim Akin, Prof. Dr. | Contact | 0049 621 383 5229 | ibrahim.akin@umm.de |
| Name | Affiliation | Role |
|---|---|---|
| Michael Behnes, PD Dr. | University Medical Center Mannheim | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medical Center Mannheim | Recruiting | Mannheim | 68167 | Germany |
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| ID | Term |
|---|---|
| D000072658 | Non-ST Elevated Myocardial Infarction |
| D000072657 | ST Elevation Myocardial Infarction |
| D009203 | Myocardial Infarction |
| D018805 | Sepsis |
| D009202 | Cardiomyopathies |
| D002311 | Cardiomyopathy, Dilated |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Withdrawl of peripheral venous blood (ca. 40ml) in EDTA, and ammonium heparin serum tubes at the time of acute disease status.
|
| Sepsis | All consecutive patients admitted with sepsis or septic shock to University Medical Center Mannheim. One venous blood withdraw will be performed. Demographic and clinical data will be documented. |
|
| Healthy controls | Clinically inapparent group as controls. One venous blood withdraw will be performed. Demographic and clinical data will be documented. |
|
| 12 months after inclusion |
| D007238 |
| Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D006332 | Cardiomegaly |
| D000083083 | Laminopathies |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |