Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism

Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism

To investigate changes in sclerostin levels following acute post-thyroidectomy hypoparathyroidism

Female patients with thyroid disorders, referred to the Department of Head and Neck Surgery, at Metaxa Anti-Cancer Hospital of Piraeus, for total thyroidectomy.

Based on the development of biochemical hypocalcemia (cCa < 8.4 mg/dl), subjects were divided into 2 groups: Group A: without postsurgical hypoparathyroidism that served as controls and group B: subjects, with acute postsurgical hypoparathyroidism.

Blood collections were performed in the morning after an overnight fast, in at least 3 different time points; preoperatively, 1st postoperative day and 7th postoperative day for the detrmination of sclerostin levels

Inclusion Criteria:

• Indication for total thyroidectomy

Exclusion Criteria:

• parathyroid disorders, chronic kidney disease (eGFR< 60 ml/min), treatment with antiosteoporosis drugs, rheumatic disease and history of long term (>1 month) or current corticosteroid use