A Pumpkin Seed, Isoflavonoid and Cranberry Mix in LUTS/BPH

Prospective Multicenter Open-label One Arm Trial Investigating a Pumpkin Seed, Isoflavonoid and Cranberry Mix in Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia

The aim is to assess the efficacy of a mix of Pumpkin Seed Extract, Soy Germ Isoflavonoids and Cranberry (Novex®) in the management of mild to moderate LUTS in BPH patients. The patients will be evaluated based on the severity of LUTS, urological quality of life, and erectile function.

This is a single-arm prospective open-label trial investigating a combination of pumpkin seed, isoflavonoid and cranberry mix in improving LUTS, urological quality of life, and erectile function in BPH patients. The compound will be administered orally two tablets daily for 3 months. Recruited patients will be seen at 3 visits: initial visit (visit 1), 1-month visit (visit 2) and 3-month visit (visit 3) and their data will be collected in a dedicated case report form.

Inclusion Criteria:

• mild to moderate LUTS due to BPH for at least 6 months at the initial visit
• no previous therapy or are still symptomatic despite the current use of alpha-blockers

Exclusion Criteria:

• International Prostate Symptom Score (IPSS) > 19
• Prostate cancer
• Urethral stenosis