Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG)

Autologous T-Cells Expressing A Chimeric Antigen Receptor Directed To B-Cell Maturation Antigen (BCMA) In Patients With Generalized Myasthenia Gravis (MG)

This is a Phase IIb study to evaluate the safety and preliminary efficacy of Descartes-08 CAR T-cells in patients with Generalized Myasthenia Gravis

Inclusion Criteria:

• Patient must be at least 18 years of age.
• Patient must have Generalized Myasthenia Gravis at the time of screening.
• Concomitant immunosuppressive drugs must be deemed necessary by the investigator.
• Seronegative Patients are included

Exclusion Criteria:

• Major chronic illness that is not well managed at the time of study entry and in the opinion of the investigator may increase the risk to the patient.
• Patient is pregnant or lactating.