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This study is looking to see how a 6-month low carbohydrate diet can affect the body's ability to use energy in addition to the affects it has on the heart and blood vessel health.
Weight gain often occurs following a liver transplant. This weight gain is problematic as it leads to many other health problems. The reasons of this weight gain are still poorly understood. To better understand weight gain, this study is looking to see how a 6-month low carbohydrate diet can affect the body's ability to use energy in addition to the affects it has on heart and blood vessel health.
This study will help researchers to better understand weight gain after a transplant. This knowledge will help doctors prevent weight gain after a liver transplant and therefore improve the health of liver transplant patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low Carbohydrate Diet | Experimental | This arm will be randomized to low carbohydrate diet |
|
| Standard Dietary Advice Control Group | Active Comparator | This arm will be randomized to control diet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control | Behavioral | Initial Weight Loss consultation 1.5 hour session on how to do implement healthy diet and then have a 2-week follow-up class. Information on how to maintain a healthy combination protein, fat and vegetables daily will be provided provided. 4 lifestyle coaching sessions Monthly visits for behavioral and dietary coaching as well as medication management. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in weight | Weight will be measured on a standardized scale in kilograms that will be zeroed out prior to the measurement | baseline to 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in metabolic flexibility | This will be measured in whole room calorimeter and reported as respiratory quotient | baseline to 6 months |
| Change in LDL-C | LDL-cholesterol will be measured using a fasting blood draw and a standard lipid panel. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mohammad Siddiqui, MD | Virginia Commonwealth University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Virginia Commonwealth University | Richmond | Virginia | 23298 | United States |
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| ID | Term |
|---|---|
| D015430 | Weight Gain |
| ID | Term |
|---|---|
| D001836 | Body Weight Changes |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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|
| LCD | Behavioral | Initial Weight Loss consultation 1.5 hour session on how to do implement healthy diet and then have a 2-week follow-up class. Information on how to maintain a LCD will be provided provided. 4 lifestyle coaching sessions Monthly visits for behavioral and dietary coaching as well as medication management. |
|
| baseline to 6 months |
| Change in total cholesterol | Total cholesterol will be measured using a fasting blood draw and a standard lipid panel. | baseline to 6 months |
| Change in small dense low-density lipoprotein | Small dense LDL will be measured using a fasting blood draw and a standard lipid panel. | baseline to 6 months |
| Change in adiposity | This will be measured on body composition MRI where subcutaneous and visceral fat will be quantified. Subcutaneous fat and visceral fat volume will measured on body composition MRI in liters (L) and standardized to body height and will be reported as liter/m2 | baseline to 6 months |