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This study aims to explore the relation of early nutritional intake, especially oral nutrition intake, with growth and body composition among very preterm or very low birth weight infants.
As the survival of very preterm infants increases, it is important to evaluate their long-term outcomes. Nutritional intake during early life was important to the growth and development in infants, especially in preterm infants. Studies found that early nutrition exposure in preterm infants can effect scored of Griffith Mental Development Scales and body fat percentage at later life. Insulin-like growth factor-1, leptin, Ghrelin, C-Peptide are associated with fat mass in children. And accumulation of fat and insulin resistance (IR) in the early postnatal period are related to metabolism diseases in adulthood. However, previous studies on nutrition and growth or the body composition of preterm infants were mostly completed in developed countries, and no relevant data were available in China. Therefore, this study aims to establish a prospective cohort of very preterm infants to observe the effects of nutritional exposure in early life on growth and body composition in later life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| very preterm infants cohort | A prospective cohort of very preterm or very low birth weight infants from birth to corrected age 18 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral nutritional intake | Other | The exposure are oral nutritional intake and all nutritional intake during early life (28 days), and insulin-like growth factor 1, leptin, Ghrelin, and C-peptide in serum at corrected age 40 gestational weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Z-scores of weight | Computed according to the Fenton preterm growth standards (2013) | at corrected age 40 gestational weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Z-scores of length/height | Computed according to the Fenton preterm growth standards (2013) | at corrected age 40 gestational weeks |
| Z-scores of head circumference | Computed according to the Fenton preterm growth standards (2013) |
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Inclusion Criteria:
Exclusion Criteria:
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Very preterm or very low birth weight infants in NICU
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| Name | Affiliation | Role |
|---|---|---|
| Weili Yan, MD, PhD | Children's Hospital of Fudan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's Hospital of Fudan University | Shanghai | Shanghai Municipality | 201102 | China |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D004435 | Eating |
| D007334 | Insulin-Like Growth Factor I |
| D020738 | Leptin |
| D054439 | Ghrelin |
| D002096 | C-Peptide |
| ID | Term |
|---|---|
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D004068 | Digestive System Physiological Phenomena |
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Serum
|
| at corrected age 40 gestational weeks |
| Z-scores of weight | Computed according to the WHO standards (2006) | at corrected age 6 months and 18 months |
| Z-scores of length/height | Computed according to the WHO standards (2006) | at corrected age 6 months and 18 months |
| Z-scores of head circumference | Computed according to the WHO standards (2006) | at corrected age 6 months and 18 months |
| Percentage of infants who achieve catch-up growth | Catch-up growth is defined as weight, length/height or head circumference equal to or above the 25th percentile for corrected age, according to the WHO standards (2006). | at corrected age 6 months and 18 months |
| Body fat free mass | assessed by air displacement plethysmography (ADP) | at corrected age 40 gestational weeks and 6 months |
| Body fat mass | assessed by air displacement plethysmography (ADP) | at corrected age 40 gestational weeks and 6 months |
| Body fat proportion | assessed by air displacement plethysmography (ADP) | at corrected age 40 gestational weeks and 6 months |
| Cognitive development outcome | It is examined by six areas of development measured by Griffith Mental Development Scales (GMDS) including locomotor, personal-social, hearing and language, eye and hand co-ordination, performance and practical reasoning. Developmental impairment is defined as a developmental quotient lying one standard deviation below the mean (<85) and includes mild impairments (70-84) and moderate/severe impairment (<70). | at corrected age 18 months |
| Intestinal flora change | The change of composition of intestinal flora in preterm infants. The composition of intestinal flora was test by 16s rRNA sequencing. | from birth to corrected age 18 months |
| D000091642 | Urogenital Diseases |
| D055688 | Digestive System and Oral Physiological Phenomena |
| D013002 | Somatomedins |
| D000096764 | Insulin-Like Peptides |
| D036341 | Intercellular Signaling Peptides and Proteins |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D001685 | Biological Factors |
| D054392 | Adipokines |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D011384 | Proinsulin |
| D061385 | Insulins |
| D010187 | Pancreatic Hormones |