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Memory influences emotional well being. Research has shown that having a negative emotional bias contributes to both emotion dysregulation and depression. Conversely, reactivating positive memories has been shown to reduce stress and symptoms of depression. In young adults, sleep is widely implicated in emotional processing, including consolidation of emotional memories. Evidence suggests that aging is associated with changes in emotion, including a positive memory bias and enhanced emotional well-being. These changes have been termed the "age-related positivity effect." However, the influence of sleep on these measures has not been investigated in healthy older individuals. The objective of this research is to understand the role of sleep in emotional memory consolidation and emotional well-being across adulthood. We hypothesize that sleep contributes to the age-related positivity effect in memory and affect. Our alternative hypothesis is that age-related decreases in sleep are responsible for reduced emotional memory processing over healthy aging.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sleep | Experimental |
| |
| Wake | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Overnight sleep | Behavioral | Participant sent home to sleep overnight wearing PSG. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Memory bias | Corrected recognition of positive versus negative pictures | 12 hr delay between encoding and recognition test |
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Inclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rebecca Spencer | Contact | (413) 545-5987 | rspencer@psych.umass.edu |
| Name | Affiliation | Role |
|---|---|---|
| Rebecca Spencer | University of Massachusetts, Amherst | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Massachusetts, Amherst | Recruiting | Amherst | Massachusetts | 01003 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25060510 | Background | Dalgleish T, Werner-Seidler A. Disruptions in autobiographical memory processing in depression and the emergence of memory therapeutics. Trends Cogn Sci. 2014 Nov;18(11):596-604. doi: 10.1016/j.tics.2014.06.010. Epub 2014 Jul 21. | |
| 26085274 | Background | Ramirez S, Liu X, MacDonald CJ, Moffa A, Zhou J, Redondo RL, Tonegawa S. Activating positive memory engrams suppresses depression-like behaviour. Nature. 2015 Jun 18;522(7556):335-9. doi: 10.1038/nature14514. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 30, 2022 | |
| Reset | Dec 22, 2022 | |
| Release | Mar 30, 2025 | |
| Reset | Apr 16, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 30, 2022 | Dec 22, 2022 | |||
| Mar 30, 2025 |
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| Wake |
| Behavioral |
Participant sent to go about normal daily routine, instructed not to nap, drink caffeine, or engage in strenuous exercise. |
|
| 25451197 | Background | Speer ME, Bhanji JP, Delgado MR. Savoring the past: positive memories evoke value representations in the striatum. Neuron. 2014 Nov 19;84(4):847-56. doi: 10.1016/j.neuron.2014.09.028. Epub 2014 Oct 30. |
| 22262901 | Background | Baran B, Pace-Schott EF, Ericson C, Spencer RM. Processing of emotional reactivity and emotional memory over sleep. J Neurosci. 2012 Jan 18;32(3):1035-42. doi: 10.1523/JNEUROSCI.2532-11.2012. |
| 27459938 | Background | Jones BJ, Schultz KS, Adams S, Baran B, Spencer RMC. Emotional bias of sleep-dependent processing shifts from negative to positive with aging. Neurobiol Aging. 2016 Sep;45:178-189. doi: 10.1016/j.neurobiolaging.2016.05.019. Epub 2016 May 27. |
| 15212836 | Background | Leigland LA, Schulz LE, Janowsky JS. Age related changes in emotional memory. Neurobiol Aging. 2004 Sep;25(8):1117-24. doi: 10.1016/j.neurobiolaging.2003.10.015. |
| 12825643 | Background | Charles ST, Mather M, Carstensen LL. Aging and emotional memory: the forgettable nature of negative images for older adults. J Exp Psychol Gen. 2003 Jun;132(2):310-24. doi: 10.1037/0096-3445.132.2.310. |
| 16154382 | Background | Mather M, Carstensen LL. Aging and motivated cognition: the positivity effect in attention and memory. Trends Cogn Sci. 2005 Oct;9(10):496-502. doi: 10.1016/j.tics.2005.08.005. |
| 11195886 | Background | Charles ST, Reynolds CA, Gatz M. Age-related differences and change in positive and negative affect over 23 years. J Pers Soc Psychol. 2001 Jan;80(1):136-51. |
| 9866191 | Background | Mroczek DK, Kolarz CM. The effect of age on positive and negative affect: a developmental perspective on happiness. J Pers Soc Psychol. 1998 Nov;75(5):1333-49. doi: 10.1037//0022-3514.75.5.1333. |
| Apr 16, 2025 |