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The objective of this study was to find if there is a possible association and the impact of epilepsy and epileptiform activity in children with SLI.
This study concentrates on the impact of epileptiform activity for childhood epilepsy on the speech and language disturbances in addition to the associated social, cognitive and intellectual dysfunctions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | 80 Patient |
| |
| Group 2 | 80 Control subject |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EEG was recorded by EEG Machines | Diagnostic Test | EEG was recorded by EEG Machines |
|
| Measure | Description | Time Frame |
|---|---|---|
| EEGs finding | EEGs finding were defined according to the followings "Normal: within the range of frequency and amplitude distribution." "Epileptiform: Describes transient background activity with a characteristic spikes, sharp waves, spike-slow wave or sharp-slow wave complexes of focal or generalized distribution". "Abnormal non-epileptiform: deviations from normal in terms of background frequency patterns, usually in the form of excessive slow activity". | 24-48 hours |
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| Measure | Description | Time Frame |
|---|---|---|
| Intelligence quotient (IQ) | An intelligence quotient (IQ) is a total score derived from several standardized tests designed to assess human intelligence. Historically, IQ is a score obtained by dividing a person's mental age score, obtained by administering an intelligence test, by the person's chronological age, both expressed in terms of years and months. The resulting fraction is multiplied by 100 to obtain the IQ score. When current IQ tests were developed, the median raw score of the norming sample is defined as IQ 100 and scores each standard deviation (SD) up or down are defined as 15 IQ points greater or less. |
Inclusion Criteria:
Exclusion Criteria:
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The study was conducted on 80 children with speech disorders in preschool children.
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| Name | Affiliation | Role |
|---|---|---|
| Esmael M Ahmed, MD | Assistant Prof of Neurology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mansoura University Hospital | Al Mansurah | Dakahlia Governorate | 35516 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30687040 | Result | Tomas E, Vissers C. Behind the Scenes of Developmental Language Disorder: Time to Call Neuropsychology Back on Stage. Front Hum Neurosci. 2019 Jan 9;12:517. doi: 10.3389/fnhum.2018.00517. eCollection 2018. | |
| Result | 2-Kraft, S.J. & De Thorne, L.S. The Brave New World of Epigenetics: Embracing Complexity in the Study of Speech and Language Disorders Current Developmental Disorders Reports . 2014; 1: 207. | ||
| Result | 3-Hillert, Dieter. Encyclopedia of Evolutionary Psychological Science, Chapter: Neurobiology of Language, Publisher: Springer, Editors Viviana Weekes-Shackelford, Todd K. Shackelford, Viviana A. Weekes-Shackelford. Neurobiology of Language.2016: pp.1-15 | ||
| 29784061 |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 8, 2019 | |
| Reset | Nov 26, 2019 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 8, 2019 | Nov 26, 2019 |
| ID | Term |
|---|---|
| D000080888 | Specific Language Disorder |
| ID | Term |
|---|---|
| D007805 | Language Development Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
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| 24-72 hours |
| social age | Evaluation of social age: using the Vineland Social Maturity Scale . VSMS was used along with a cognitive assessment to help make a diagnosis of mental retardation or intellectual disability. It has also been used extensively to assess the development of activities of everyday life. | 24-48 hours |
| cognitive age | Evaluation of cognitive age (mental age): using the Stanford Binet Intelligence Scale. The Stanford-Binet test is a examination meant to gauge intelligence through five factors of cognitive ability. These five factors include fluid reasoning, knowledge, quantitative reasoning, visual-spatial processing and working memory. Both verbal and nonverbal responses are measured. | 24-48 hours |
| language assessment | Language evaluation: by Comprehensive Arabic Language Test (CALT). The CALT was constructed by the members of the Department of Phoniatrics at Alexandria Main University Hospital, Egypt, to form a detailed comprehensive assessment battery for Arabic language and test its reliability and validity to use it in the early detection of subtle changes in the various components of language in cases of language impaired children. | 24-72 hours |
| Result |
| Laasonen M, Smolander S, Lahti-Nuuttila P, Leminen M, Lajunen HR, Heinonen K, Pesonen AK, Bailey TM, Pothos EM, Kujala T, Leppanen PHT, Bartlett CW, Geneid A, Lauronen L, Service E, Kunnari S, Arkkila E. Understanding developmental language disorder - the Helsinki longitudinal SLI study (HelSLI): a study protocol. BMC Psychol. 2018 May 21;6(1):24. doi: 10.1186/s40359-018-0222-7. |
| Result | Ghandour H, Eldin SK, Sallam Y, Mahmoud S. Associated comorbidities of specific language impairment. Benha Med J. 2018; 35:115-21. |
| Result | Carol Westby. Social-Emotional Outcomes for Children With SLI . Word of Mouth. 2017 ; 28 (4):1-5. |
| 27186225 | Result | Kim EH, Ko TS. Cognitive impairment in childhood onset epilepsy: up-to-date information about its causes. Korean J Pediatr. 2016 Apr;59(4):155-64. doi: 10.3345/kjp.2016.59.4.155. Epub 2016 Apr 30. |
| 27570381 | Result | Syam UK, Thomas SV. Epileptiform activity in the electroencephalogram of 6-year-old children of women with epilepsy. Ann Indian Acad Neurol. 2016 Jul-Sep;19(3):318-22. doi: 10.4103/0972-2327.179974. |
| 25323031 | Result | Holmes GL. What is more harmful, seizures or epileptic EEG abnormalities? Is there any clinical data? Epileptic Disord. 2014 Oct;16 Spec No 1(Spec No 1):S12-22. doi: 10.1684/epd.2014.0686. |
| 28666338 | Result | Ung H, Cazares C, Nanivadekar A, Kini L, Wagenaar J, Becker D, Krieger A, Lucas T, Litt B, Davis KA. Interictal epileptiform activity outside the seizure onset zone impacts cognition. Brain. 2017 Aug 1;140(8):2157-2168. doi: 10.1093/brain/awx143. |
| 26597089 | Result | McTague A, Howell KB, Cross JH, Kurian MA, Scheffer IE. The genetic landscape of the epileptic encephalopathies of infancy and childhood. Lancet Neurol. 2016 Mar;15(3):304-16. doi: 10.1016/S1474-4422(15)00250-1. Epub 2015 Nov 17. |
| 25710839 | Result | Staley K. Molecular mechanisms of epilepsy. Nat Neurosci. 2015 Mar;18(3):367-72. doi: 10.1038/nn.3947. Epub 2015 Feb 24. |
| 30298240 | Result | Faught E, Karakis I, Drane DL. The Impact of Interictal Discharges on Performance. Curr Neurol Neurosci Rep. 2018 Oct 8;18(12):88. doi: 10.1007/s11910-018-0892-9. |
| 31366163 | Result | Luz-Escamilla L, Morales-Gonzalez JA. Association between Interictal Epileptiform Discharges and Autistic Spectrum Disorder. Brain Sci. 2019 Jul 30;9(8):185. doi: 10.3390/brainsci9080185. |
| 30214992 | Result | Kane N, Acharya J, Benickzy S, Caboclo L, Finnigan S, Kaplan PW, Shibasaki H, Pressler R, van Putten MJAM. A revised glossary of terms most commonly used by clinical electroencephalographers and updated proposal for the report format of the EEG findings. Revision 2017. Clin Neurophysiol Pract. 2017 Aug 4;2:170-185. doi: 10.1016/j.cnp.2017.07.002. eCollection 2017. No abstract available. |
| 25847431 | Result | Ghacibeh GA, Fields C. Interictal epileptiform activity and autism. Epilepsy Behav. 2015 Jun;47:158-62. doi: 10.1016/j.yebeh.2015.02.025. Epub 2015 Apr 3. |
| Result | Shweta Singh, Shivani Pandey, Vivek Agarwal. A Comparative study of Vineland Adaptive Behavior Scale II and Vineland Social Maturity Scale on children and adolescents with Intellectual Disability J. Indian Assoc. Child Adolesc. Ment. Health 2019; 15(1):27-38. |
| Result | El-Maghraby R. Comprehensive Arabic Language test as a tool for assessing delayed language impaired Egyptian children [MD thesis]. Alexandria: Faculty of Medicine, Alexandria University;2008. |
| 26237464 | Result | Moreno MA. Speech and Language Delays in Young Children. JAMA Pediatr. 2015 Aug;169(8):796. doi: 10.1001/jamapediatrics.2014.2146. No abstract available. |
| Result | Fadhli, Khadija & Al-Bunaian, Nada. Prevalence and Social Influences of Delayed Language Development in Preschool-Age Saudi Children. International Journal of Science and Research. 2017:6. 6-391. |
| 26152671 | Result | Wallace IF, Berkman ND, Watson LR, Coyne-Beasley T, Wood CT, Cullen K, Lohr KN. Screening for Speech and Language Delay in Children 5 Years Old and Younger: A Systematic Review. Pediatrics. 2015 Aug;136(2):e448-62. doi: 10.1542/peds.2014-3889. Epub 2015 Jul 7. |
| 25142091 | Result | Reilly S, Tomblin B, Law J, McKean C, Mensah FK, Morgan A, Goldfeld S, Nicholson JM, Wake M. Specific language impairment: a convenient label for whom? Int J Lang Commun Disord. 2014 Jul-Aug;49(4):416-51. doi: 10.1111/1460-6984.12102. |
| 22928858 | Result | Kalnak N, Peyrard-Janvid M, Sahlen B, Forssberg H. Family history interview of a broad phenotype in specific language impairment and matched controls. Genes Brain Behav. 2012 Nov;11(8):921-7. doi: 10.1111/j.1601-183X.2012.00841.x. Epub 2012 Sep 20. |
| 29241678 | Result | Baumer FM, Cardon AL, Porter BE. Language Dysfunction in Pediatric Epilepsy. J Pediatr. 2018 Mar;194:13-21. doi: 10.1016/j.jpeds.2017.10.031. Epub 2017 Dec 11. No abstract available. |
| 26316868 | Result | Tuchman R. Autism and Cognition Within Epilepsy: Social Matters. Epilepsy Curr. 2015 Jul-Aug;15(4):202-5. doi: 10.5698/1535-7511-15.4.202. |
| Result | Hamdy M. Bedair, Mona K. Mohamed, Rania M. Abdou, Faten I. El Kafrawy. Concurrent language disorders in children with idiopathic epilepsy. Egyptian Journal of Otolaryngology. 2017: 33 (3): 603-609. |
| 26417549 | Result | Mehta B, Chawla VK, Parakh M, Parakh P, Bhandari B, Gurjar AS. EEG Abnormalities in Children with Speech and Language Impairment. J Clin Diagn Res. 2015 Jul;9(7):CC04-7. doi: 10.7860/JCDR/2015/13920.6168. Epub 2015 Jul 1. |
| 20471326 | Result | Jones JE, Siddarth P, Gurbani S, Shields WD, Caplan R. Cognition, academic achievement, language, and psychopathology in pediatric chronic epilepsy: Short-term outcomes. Epilepsy Behav. 2010 Jul;18(3):211-7. doi: 10.1016/j.yebeh.2010.03.015. Epub 2010 May 14. |
| 26293670 | Result | Sanchez Fernandez I, Loddenkemper T, Galanopoulou AS, Moshe SL. Should epileptiform discharges be treated? Epilepsia. 2015 Oct;56(10):1492-504. doi: 10.1111/epi.13108. Epub 2015 Aug 21. |
| 19207301 | Result | Parry-Fielder B, Collins K, Fisher J, Keir E, Anderson V, Jacobs R, Scheffer IE, Nolan T. Electroencephalographic abnormalities during sleep in children with developmental speech-language disorders: a case-control study. Dev Med Child Neurol. 2009 Mar;51(3):228-34. doi: 10.1111/j.1469-8749.2008.03163.x. Epub 2009 Jan 29. |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D007859 | Learning Disabilities |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |