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Transcranial direct current stimulation (tDCS) combined with computerized cognitive addiction therapy(CCAT) for methamphetamine(MA) dependent patients in voluntary drug rehabilitation center. Electronic medical systems were applied for drug related knowledge education, self-evaluation and outpatient follow-up reminder after intervention in order to reduce relapse behaviors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| True tDCS Combined With CCAT | Active Comparator | Ture transcranial direct current stimulation (tDCS) intervention combined with computerized cognitive addiction therapy(CCAT) group, last 25 minutes per day for 4 weeks(5 days/week). Electronic follow-up for 6 month including drug knowledge every week, self-evaluation every two weeks and outpatient follow-up reminder every four weeks. |
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| Sham tDCS Combined With CCAT | Sham Comparator | Sham transcranial direct current stimulation (tDCS) intervention combined with computerized cognitive addiction therapy(CCAT) group, last 25 minutes per day for 4 weeks(5 days/week). Electronic follow-up for 6 month including only outpatient follow-up reminder every four weeks. |
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| Control group | No Intervention | During the treatment, the participants in control group only received treatment such as education of psychology, health and judicature, physical training as well as vocational training as usual in the compulsory rehabilitation center. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ture Transcranial Direct Current Stimulation (tDCS) | Device | Ture 1-2 mA current of tDCS intervention in patients' binary brain DLPFC areas(20 mm). |
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| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline cue-induced craving at 2 weeks | Participants were instructed to watch methamphetamine-related videos by VR and rate their level of craving after smelling and recalling the last time they engaged in drug use. Craving was assessed by visual analog scales (VAS), with 0 mm being "no craving"and 100 mm representing "most craving ever experienced for methamphetamine". | 2 weeks |
| Change from Baseline cue-induced craving at 4 weeks | Participants were instructed to watch methamphetamine-related videos by VR and rate their level of craving after smelling and recalling the last time they engaged in drug use. Craving was assessed by visual analog scales (VAS), with 0 mm being "no craving"and 100 mm representing "most craving ever experienced for methamphetamine". | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Attention bias towards methamphetamine | A Chinese version of the MA addiction dot probe task (DPT) is used to evaluate the attention bias towards drugs. | 2 weeks,4 weeks |
| cognitive function | Chinese version of the CogState Battery was used to assess cognitive function. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Na Zhong, Doctor, doctor | Contact | 008613671644472 | winco917@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Na Zhong, doctor | Shanghai Mental Health Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Mental Health Center | Recruiting | Shanghai | China |
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| Sham Transcranial Direct Current Stimulation (tDCS) | Device | Sham tDCS intervention in patients' binary brain DLPFC areas(20 mm). |
|
| 2 weeks,4 weeks |
| response inhibition function | stop signal task | 2 weeks,4 weeks |
| reward-related function | Delay Discounting Task | 2 weeks,4 weeks |