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The purpose of this study is to evaluate testicular function measured as testosterone level and semen quality.
Men having undergone surgery for testicular torsion between 01.01.2003 - 12.31.2012 will receive a invitation to participate in this study. It is expected that 110 patients can be identified and about 65% of them will participate. These men will undergo a andrological evaluation, deliver a semen sample, have a blood sample taken and undergo a testicular ultrasound.
Control group:
Men attending the fertility counseling at Herlev hospital will be offered participation in this study. The fertility counseling demands that men who contact the clinic have never had their sperm analyzed, have not tried to get pregnant with their partner for more than a year and that they have no prior knowledge of their fertility.
Primary endpoint:
Secondary endpoint:
Semen parameters
Hormones
Data points:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Testicular torsion group | Men having undergone surgery for testicular torsion between 01.01.2003 and 12.31.2012 | ||
| Control group | Men without knowledge of their fertility status and who have never had their semen analyzed |
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| Measure | Description | Time Frame |
|---|---|---|
| Sperm concentration | Amount of motile sperm cells (* 10^6) | 8-17 years after surgical intervention |
| Testosterone level | ng/ml | 8-17 years after surgical intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Semen parameters as an indicator of overall testicular exocrine function | Compared with results from control group | 8-17 years after surgical intervention |
| Hormone level as an indicator of testicular endocrine function |
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Inclusion Criteria:
Exclusion Criteria:
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Men with a verified testicular torsion operated at Herlev and Gentofte hospital between 01.01.2003 and 12.31.2012. This ensures atleast 5 years of follow up.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Frederik M Jacobsen | Contact | 38688949 | frederik.moeller.jacobsen.01@regionh.dk | |
| Trine Møller Rudlang, MD | Contact | Trine.møller.rudlang@regionh.dk |
| Name | Affiliation | Role |
|---|---|---|
| Jens Sønksen, Professor | Herlev and Gentofte Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Growth and Reproduction | Recruiting | Copenhagen | 2100 | Denmark |
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| ID | Term |
|---|---|
| D013086 | Spermatic Cord Torsion |
| ID | Term |
|---|---|
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
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Follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, estradiol, inhibin B, sex hormone-binding globulin, albumin
| 8-17 years after surgical intervention |
| MAR test result correlated to the type of surgery | MAR test of sperm cells | 8-17 years after surgical intervention |
| Difference in sperm morphology and motility correlated to the type of surgery and compared to control group | Morphology and motility (%) | 8-17 years after surgical intervention |
| Paternity as a measure of fertility | Number of kids if any. | 8-17 years after surgical intervention |