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Prospective, monocentric, non-interventional study in patients placed on extracorporeal membrane oxygenation (ECMO)
Our hypothesis is that ECMO initiation is responsible for a severe decrease of antithrombin level in a high proportion of patients who develop heparin resistance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Extracorporeal membrane oxygenation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood sample | Biological | Blood sample collection from a peripheral catheter at ECMO initiation (H0), then 2h, 6h, 12h, 24h and daily from day 2 to day 7 or at ECMO discontinuation |
| Measure | Description | Time Frame |
|---|---|---|
| To study antithrombin level from during the first 24h after ECMO initiation | Blood sample at ECMO initiation (H0), then 2h, 6h, 12h, 24h and daily from day 2 to day 7 or at ECMO discontinuation | Day 7 |
| Measure | Description | Time Frame |
|---|---|---|
| To study antithrombin level 24h after initialization of ECMO | Blood sample at 24h | Hour 24 |
| To study the prevalence of antithrombin (AT) deficiency (≤70%) at each time point (from H0 to day 7) |
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Inclusion Criteria:
Exclusion Criteria:
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Patient with cardiac insifficiency placed on extracorporeal membrane oxygenation (ECMO)
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Rennes | Rennes | 35033 | France |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Blood sample
| Day 7 |
| To study relationship between antithrombin level and heparin resistance | Blood sample | Day 7 |
| To study relationship between antithrombin level and thrombin generation test | Blood sample | Day 7 |
| To study clinical factors associated with AT deficiency | Blood sample | Day 7 |
| To describe clinical evolution of patients according to initial AT level | Blood sample | Hour 0 |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |