Prospective Observational Study of the Sacubitril-Valsartan Treatment Effectiveness.

Prospective Observational Study of the Sacubitril-Valsartan Treatment Effectiveness.

The aim of this prospective study is to demonstrate if there is any difference in the treatment response to Sacubitril-Valsartan depending on the ventricular disfunction ethiology in patients with severe systolic disfunction heart failure.

Inclusion Criteria:

• Patients older than 18 years old.
• Ejection fraction (EF) ≤ 40%.
• Treated with optimal medical treatment for at least 3 months and remained in functional class II, III or IV.
• Patients with ischemic or non ischemic etiology.

Exclusion Criteria:

• Patients with enolic etiology.
• Patients with any contraindication for taking Sacubitril-Valsartan.
• Patients with EF >40%.