Study on Skin Microbiome of HFS

Study on Skin Microbiota of Hand Foot Syndrome

To skin microecology and breast cancer chemotherapy drug therapy as the breakthrough point, disease prevention and treatment of breast cancer in China, the important scientific problems in basic research, through in-depth study of skin micro ecological changes in advanced breast cancer chemotherapy and its regulatory mechanism, clear skin flora occurred after application of capecitabine and the influence and mechanism of the immune response;Finding markers for the treatment and prognosis of related diseases;Identify and isolate key strains and/or metabolites, and conduct intervention studies to reveal new mechanisms of skin microflora homeostasis and toxic and side effects of breast cancer chemotherapy.

To skin microecology and breast cancer chemotherapy drug therapy as the breakthrough point, disease prevention and treatment of breast cancer in China, the important scientific problems in basic research, through in-depth study of skin micro ecological changes in advanced breast cancer chemotherapy and its regulatory mechanism, clear skin flora occurred after application of capecitabine and the influence and mechanism of the immune response;Finding markers for the treatment and prognosis of related diseases;Identify and isolate key strains and/or metabolites, and conduct intervention studies to reveal new mechanisms of skin microflora homeostasis and toxic and side effects of breast cancer chemotherapy

Inclusion Criteria:

• age: 18-65 years old
• advanced breast cancer patients
• healthy volunteers

Exclusion Criteria:

• previous skin disease history, or other skin disease activity at present
• various antibiotics, prebiotics, probiotics or lactic acid products used within three months;
• having a history of alcoholism for more than 2 years and smoking for years;
• pregnancy or lactation;
• have oral, respiratory and gastrointestinal diseases;
• other metabolic diseases, such as obesity, hypertension, diabetes, stones, and liver diseases;
• other autoimmune diseases, such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease;
• history of gastrointestinal surgery;
• family genetic history, history of mental illness, etc.;
• the subject is participating in other research projects;
• other reasons are not considered suitable for continued clinical trials.