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This study evaluates whether increasing sleep duration can increase neural and behavioral response to rewards and decrease depressive symptoms in 18- to 22-year-old women with insufficient sleep and depressive symptoms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Extended sleep opportunity | Experimental |
| |
| Typical sleep opportunity | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Typical sleep opportunity | Behavioral | Typical sleep opportunity with consistent sleep timing for 1 week |
|
| Measure | Description | Time Frame |
|---|---|---|
| Depressive symptoms | Center for Epidemiological Studies Depression Scale score. The CESD-R is a 20-item measure of the frequency of depressive symptoms, with each item rated on a scale from 0 (not at all or less than one day) to 5 (nearly every day). Total scores range from 0 to 100, with higher scores indicating greater number and frequency of depressive symptoms. | 1 week |
| Reward-related brain function | BOLD fMRI response during Reward Guessing Task | 1 week |
| Sleep duration | Mean actigraphy-measured sleep duration | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Positive affect | International Positive and Negative Affect Scale Short Form - Positive Affect score. The I-PANAS-SF is a 10-item scale that asks participants to rate the extent to which 5 positive and 5 negative adjectives describe them on a scale of 1 (never) to 5 (always). Scores for each positive adjective are summed to produce a Positive Affect (PA) score ranging from 5 to 25, with higher scores indicating more positive affect. |
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Inclusion Criteria:
Exclusion Criteria:
Participant eligibility is based on self-representation of gender identity
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| Name | Affiliation | Role |
|---|---|---|
| Melynda D Casement, PhD | University of Oregon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Oregon | Eugene | Oregon | 97403 | United States |
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| ID | Term |
|---|---|
| D003863 | Depression |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| Extended sleep opportunity | Behavioral | Extended sleep opportunity by 90 min per night with consistent sleep timing for 1 week |
|
| 1 week |
| Negative affect | International Positive and Negative Affect Scale Short Form - Negative Affect score. The I-PANAS-SF is a 10-item scale that asks participants to rate the extent to which 5 positive and 5 negative adjectives describe them on a scale of 1 (never) to 5 (always). Scores for each negative adjective are summed to produce a Negative Affect (PA) score ranging from 5 to 25, with higher scores indicating more negative affect. | 1 week |
| Reward effort | Effort Expenditure for Rewards Task score | 1 week |
| Reward-related functional connectivity | BOLD fMRI psychophysiological striatal-medial prefrontal cortex interaction | 1 week |