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Diabetic foot ulcer is the commonest cause of severe limb ischemia in diabetes mellitus And development of anemia is an additional burden to the microvascular complications of diabetes
HBA1C is the predominant Hemoglobin found in HBA1 fraction and it constitutes 5% of total Hemoglobin in normal adults and up to 15%in patients with diabetes mellitus HBA1C is used to diagnose diabetes and to identify individuals that are at high risk for developing diabetes Iron deficiency anemia is one of the most prevalent form of malnutrition affect 1,62 billion people whish correspond to 24,8%of the world population Ferritin is the storage form of iron so it is found to be test for distinguishing those with iron deficiency anemia from those who are not iron deficient
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| diabetic foot ulcer (1and2)with iron defic | 50 diabetic patients with diabetic foot ulcer grade (1and2) with iron deficiency anemia will be applied TO
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| |
| diabetic foot ulcer grade(1and2)without iron deficiency anemia | 50 patients with diabetic foot ulcer grade (1and2) without iron deficiency anemia will be applied to
|
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CBC ,Serum ferritin ,HBA1C | Diagnostic Test | Diabetic patients will be applied to CBC, HBA1C and serum ferritin |
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| Measure | Description | Time Frame |
|---|---|---|
| Iron deficiency detected by Hemoglobin level in g/dl HBA1C level in diabetic patients | The influence of iron deficiency anemia on HBA1C in diabetic patients | Base line |
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Inclusion Criteria:
Exclusion Criteria:
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Diabetic patients with diabetic foot ulcer grade one and two with or without iron deficiency anemia
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marina Samir Fawzy, Resident | Contact | 01271389378 | Drmarinasamirfawzy@gmail.com | |
| Manal Al Sayed Ezz El Deen, Associated professor | Contact | 01005826070 | Manal_ezeldeen@yahoo.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21679130 | Background | Kim S, Min WK, Chun S, Lee W, Park HI. Glycated albumin may be a possible alternative to hemoglobin A1c in diabetic patients with anemia. Clin Chem Lab Med. 2011 Oct;49(10):1743-7. doi: 10.1515/CCLM.2011.646. Epub 2011 Jun 17. | |
| 20042775 | Background | American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010 Jan;33 Suppl 1(Suppl 1):S62-9. doi: 10.2337/dc10-S062. No abstract available. |
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| ID | Term |
|---|---|
| D018798 | Anemia, Iron-Deficiency |
| ID | Term |
|---|---|
| D000747 | Anemia, Hypochromic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| 20067959 | Background | Kim C, Bullard KM, Herman WH, Beckles GL. Association between iron deficiency and A1C Levels among adults without diabetes in the National Health and Nutrition Examination Survey, 1999-2006. Diabetes Care. 2010 Apr;33(4):780-5. doi: 10.2337/dc09-0836. Epub 2010 Jan 12. |
| 23757434 | Background | Wolffenbuttel BH, Herman WH, Gross JL, Dharmalingam M, Jiang HH, Hardin DS. Ethnic differences in glycemic markers in patients with type 2 diabetes. Diabetes Care. 2013 Oct;36(10):2931-6. doi: 10.2337/dc12-2711. Epub 2013 Jun 11. |
| 24357215 | Background | American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014 Jan;37 Suppl 1:S81-90. doi: 10.2337/dc14-S081. No abstract available. |
| D000090463 |
| Iron Deficiencies |
| D019189 | Iron Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |