Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This neuroimaging study is a clinical trial investigating the effectiveness of intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to the inferior parietal lobule (IPL) in reducing suicide risk in patients with major depressive episode (MDE) or borderline personality disorder (BPD).
This neuroimaging study aims to determine the effectiveness of iTBS-TMS to the IPL in reducing suicide risk in patients with MDE or BPD. This study also aims to identify the structural and functional circuit properties that characterized the suicidal brain and the signatures that explain the clinical severity of suicidal risk. Moreover, this study aims to determine biological and dimensional predictors of anti-suicidal response to iTBS-TMS and its mechanism of action.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MDE and Active iTBS-TMS | Experimental | This group will consist of patients diagnosed with MDE that are receiving active iTBS-TMS. |
|
| BPD and Active iTBS-TMS | Experimental | This group will consist of patients diagnosed with BPD that are receiving active iTBS-TMS. |
|
| MDE and Sham iTBS-TMS | Sham Comparator | This group will consist of patients diagnosed with MDE that are receiving sham iTBS-TMS. |
|
| BPD and Sham iTBS-TMS | Sham Comparator | This group will consist of patients diagnosed with BPD that are receiving sham iTBS-TMS. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intermittent Theta Burst Transcranial Magnetic Stimulation (Active) | Device | iTBS-TMS is a noninvasive neuromodulation technique that uses a powerful magnet to induce focal electrical currents in target brain regions. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Functional Connectivity of Key Nodes | Measured using Magnetic Resonance Imaging | Through Treatment Completion, Average of 3 Days |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| DNN Inbox | Contact | 6177248780 | mghdnn@mgh.harvard.edu |
| Name | Affiliation | Role |
|---|---|---|
| Joan Camprodon, MD/PhD | 6177265348 | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Recruiting | Boston | Massachusetts | 02129 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Intermittent Theta Burst Transcranial Magnetic Stimulation (Sham) | Device | The sham version of iTBS-TMS involves placing the magnet over the same target brain region but the device will not be turned on during the treatment. There will be two electrodes placed on the scalp that mimic the sensation of iTBS-TMS but does not induce focal electrical currents. |
|
|
| ID | Term |
|---|---|
| D001883 | Borderline Personality Disorder |
| D013405 | Suicide |
| ID | Term |
|---|---|
| D010554 | Personality Disorders |
| D001523 | Mental Disorders |
| D016728 | Self-Injurious Behavior |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
Not provided
Not provided