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Retrospective study that aims to examine the presence of acute kidney injury (AKI) during major abdominal surgery, non- cardiac surgery. Using clinical and biochemical data in order to establish AKI frequency and risk factors.
Ethical approval was submitted and approved by the regional ethical committee, Etisk prövningsnämnd Uppsala, # 2017/418.
Patients were selected from the time span of april 2016 to september 2017. The investigators identified 499 patients that had undergone any of the selected procedures. The procedures were, pancreatic resection, HIPEC surgery in colorectal setting, gynecological debulking in metastasized ovarian cancer, and liver resection.
The risk of acute kidney injury (AKI) by the KDIGO definition during the postoperative period will be estimated in the group as a whole, and for each type of surgery separately. In addition the data will be stratified by sex to investigate systematic gender disparities or physiological differences. Length of stay, thirty day and sixty day mortality will secondary endpoints.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pancreatic resection | |||
| Liver resection | |||
| HIPEC surgery | |||
| Gynecological debulking surgery |
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| Measure | Description | Time Frame |
|---|---|---|
| Incidence of AKI | Frequency of AKI as defined by KDIGO | the first 24- 72 hours postop |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | 30, 60, and 360 day mortality rate | 30, 60 and 360 days postoperatively |
| Major Adverse Kidney Events | Renal composite outcome according to Major Adverse Kidney Events (MAKE) |
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Inclusion Criteria:
Any of the selected procedures.
Exclusion Criteria:
Patient has expressed his or her will to nor participate in any study.
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Swedish population undergoing cancer surgery with four selected procedures. Age span between 19 and 85 years old.
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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Blood samples collected one year ahead of surgery and one year after surgery.
| 30, 60 and 360 days postoperatively |
| Fluid balance | Fluid balance during surgery, and the first postoperative days. | 24-72h |
| Electrolyte disturbances | Any electrolyte disturbance. | 24-72h |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |