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The project will apply the methods of clinical observation experiment to study the central transport characteristics of flurbiprofen axetil by detecting S-flurbiprofen and R-flurbiprofen concentrations in cerebral-spinal fluid(CSF) after intravenous injection of flurbiprofen axetil in elderly patients.
The patients undergoing spinal anesthesia for lower extremity surgery will be studied. Flurbiprofen axetil 100mg will be injected intravenously. CSF 1ml and blood 2ml will be obtained simultaneously every 5 minutes after intravenous injection in 50 min( T1~T10).CSF and blood samples will be used to detected S-flurbiprofen and R-flurbiprofen concentrations by using Liquid Chromatography-Mass Spectrometry. And the CSF/blood S-flurbiprofen and R-flurbiprofen concentrations ratio were calculated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| T1 | At 5 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | ||
| T2 | At 10 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | ||
| T3 | At 15 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | ||
| T4 | At 20 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | ||
| T5 | At 25 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected | ||
| T6 | At 30 minutes after flurbiprofen axetil injected intravenously, 14 patients' samples were required to be collected,including 7 younger patients | ||
| T7 |
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| Measure | Description | Time Frame |
|---|---|---|
| The concentrations of S-flurbiprofen and R-flurbiprofen in plasma and CSF of all patients. | The samples will be used to be determined plasma and CSF drug concentrations. | perioperation |
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Inclusion Criteria:
Exclusion Criteria:
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ASA I or lII, both sexes, aged 18-85 yr
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yi Feng, MD | Contact | 08601088325590 | yifeng65@sina.com | |
| Han Yao | Contact | 08601088325581 | yaohan2016@sina.com |
| Name | Affiliation | Role |
|---|---|---|
| Yi Feng, MD | Peking University People's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University People's Hospital | Recruiting | Beijing | Beijing Municipality | 100044 | China |
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At 35 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected
| T8 | At 40 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected |
| T9 | At 45 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected |
| T10 | At 50 minutes after flurbiprofen axetil injected intravenously, 7 aged patients' samples were required to be collected |