1. All patients underwent computed tomography (CT) 3-5 days before surgery. The collimation is 2.5 mm and CT Planning System.
2. Delineation of the gross tumor volume (GTV) and adjacent organs at risk (OARs);
3. Determination of the needle tract of the implanted insertion direction, distribution, and depth. Then calculation of the dose distribution of the target volume and OARs.
4. Depending on B-TPS data, we establish a digital model for the individual template.
5. Local anesthesia or intraspinal anesthesia was induced in all patients. The three-dimensional printing noncoplanar templates (3D-PNCT) was placed on the surface of the treatment area of the patient. The 3D-PNCT was aligned accurately with the outer-contour features. Through the guide hole of the 3D-PNCT, we inserted to pre-planned depths.
6. Delineation of the GTV and design planning .
7. Connect the source tube and 192Ir high dose rate interorganizational brinotherapy
8. At the end pressed to stop bleeding.

Local progression free survival was defined as the time from the implantation of the treatment to the treatment of local tumor progression.

Tumor size changes were monitored using CT. According to the solid tumor treatment efficacy evaluation standard RECIST, evaluation results including complete response, partial response, stable disease, and progression disease.Tumor response rate was complete response rate plus partial response rate.

Overall survival was defined as the time from the implantation of the treatment to the death of any cause.

Number of participants with treatment-related acute adverse events were evaluated according to RTOG acute radiation injury grading standards; Number of participants with treatment-related late adverse events were evaluated according to RTOG/ EORTC advanced radiation injury grading schemes.