High Dose Rate Interstitial Brachytherapy With Three Dimensional Printing Template for Recurrent Gynecologic Tumors

Clinical Study on Pelvic Recurrence of Gynecologic Tumors After External Irradiation by Three Dimensional Printing Personalized Template Assisted With 192Ir High Dose Rate Interstitial Brachytherapy

This is a single-center study.Eligible patients will have histologically proven pelvic recurrence of cervical cancer after radiotherapy .

The results of treatment, examination and follow-up of patients with recurrent cervical cancer after radiotherapy who recieved imaging guided three dimensional printing personalized template assisted with 192Ir high dose rate interorganizational braided therapy were statistically analyzed .

Inclusion Criteria:

• Patients with histologically confirmed pelvic recurrence of cervical cancer.
• Age ≥ 18 years and ≤ 75 years.
• Previous accept pelvic radiotherapy;
• Karnofsky ≥60；
• Patients reject or cannot tolerate surgery;
• Received 192Ir high dose rate intertissue salvage therapy;
• Ultrasound guidance or computed tomography guidance;
• Regular review and follow-up.

Exclusion Criteria:

• Patients participated in clinical trials of other drugs within four weeks;
• The patient had a previous history of bleeding, and any bleeding event with severity rating of CTCAE5.0 or above occurred within 4 weeks prior to screening;
• There are any puncture taboos.
• Patients with severe cardiovascular and cerebrovascular diseases.
• Unable to treat as planned.
• Patients lack major indicators and cannot participate in post-treatment review and follow-up.