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| Name | Class |
|---|---|
| Sleep Number Corporation | UNKNOWN |
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The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences. The investigators will compare Somali patients with known obstructive sleep apnea (OSA) to individuals without OSA, and to individuals of other ethnic/racial origins to determine the risk factors (genetic and/or physiologic) associated with developing cardiovascular diseases. This will help the investigators to understand the unique sleep pathology of individuals of African descent.
Participants can be healthy volunteers or volunteers diagnosed with obstructive sleep apnea. All patients may undergo a sleep study (i.e. hospital or home-based), physical examination, questionnaires, blood and urine samples, ultrasound scan of the heart and brachial artery in the arm, CT scan, DEXA scan, paced breathing test, cardiopulmonary test and chemo-sensitivity test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Somali Descent | Study participants who are of Somali origin. | ||
| Non-Somali Descent | Study participants who are not of Somali origin. |
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| Measure | Description | Time Frame |
|---|---|---|
| To assess the prevalence of obstructive sleep apnea | Measure the apnea-hypopnea index (AHI) to determine burden of obstructive sleep apnea. Based on the AHI, sleep apnea will be diagnosed if the AHI is ≥5 events/hour. | 10 years |
| To determine the severity of obstructive sleep apnea | The severity of OSA is classified based on the AHI as follows: None/Minimal: AHI < 5 per hour, Mild: AHI ≥ 5, but < 15 per hour, Moderate: AHI ≥ 15, but < 30 per hour, Severe: AHI ≥ 30 per hour. | 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| 24 hour mean arterial pressure | Ambulatory measure of blood pressure in mmHg | 10 years |
| Vascular endothelial function | Change in brachial artery diameter in response to hyperemia |
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Inclusion Criteria:
Exclusion Criteria:
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The study population are individuals who are of Somali descent compared to those of different racial/ethnic origins.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Somers CPL Lab | Contact | 507-422-3499 | CPLSOMALI@mayo.edu |
| Name | Affiliation | Role |
|---|---|---|
| Virend Somers, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic | Recruiting | Rochester | Minnesota | 55905 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40088388 | Derived | Greenlund IM, Bock JM, Govindan N, Kantas D, Singh P, Covassin N, Somers VK. Blood Pressure and Heart Rate Response to Orthostasis in Somali Americans. J Racial Ethn Health Disparities. 2026 Jun;13(3):1961-1966. doi: 10.1007/s40615-025-02389-7. Epub 2025 Mar 15. | |
| 39502777 | Derived | Greenlund I, Bock J, Govindan N, Kantas D, Singh P, Covassin N, Somers V. Blood Pressure and Heart Rate Response to Orthostasis in Somali Americans. Res Sq [Preprint]. 2024 Oct 21:rs.3.rs-4925722. doi: 10.21203/rs.3.rs-4925722/v1. |
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| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| D012891 | Sleep Apnea Syndromes |
| D002318 | Cardiovascular Diseases |
| D003075 | Coitus |
| D012120 | Respiration Disorders |
| D006973 | Hypertension |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D001049 | Apnea |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
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Blood plasma, buffy coat, and serum.
| 10 years |
| Insulin sensitivity | Oral glucose tolerance testing | 10 years |
| Body composition | Percentage body fat content | 10 years |
| 39182475 | Derived | Greenlund IM, Kantas D, Prakash SS, Bock JM, Covassin N, Somers VK. Nocturnal Hemodynamics in Somali Americans: Implications for Cardiovascular Risk. Am J Nephrol. 2024;55(6):629-637. doi: 10.1159/000540987. Epub 2024 Aug 24. |
| D012893 |
| Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D012725 | Sexual Behavior |
| D001519 | Behavior |
| D014652 | Vascular Diseases |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |