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| Name | Class |
|---|---|
| New York Presbyterian Hospital | OTHER |
| Sunnybrook Health Sciences Centre | OTHER |
| Cedars-Sinai Medical Center | OTHER |
| Columbia University |
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The central hypothesis of ROMA:Women is that the use of multiple arterial grafting (MAG) will improve clinical outcomes and quality of life (QOL) compared to single arterial grafting (SAG).
The specific aims of ROMA:Women are:
Aim 1: Determine the impact of MAG vs SAG on major adverse cardiac and cerebrovascular events in women undergoing coronary artery bypass grafting (CABG). The investigators will compare major adverse cardiac and cerebrovascular events (death, stroke, non-procedural myocardial infarction, repeat revascularization, and hospital readmission for acute coronary syndrome or heart failure) in a cohort of 2,300 women randomized 1:1 to MAG or SAG. Differences by important clinical and surgical subgroups (patients younger or older than 70 years, diabetics, racial and ethnic minorities, on vs off pump CABG, type of arterial grafts used) will also be evaluated. The women enrolled in the ongoing ROMA trial (anticipated to be approximately 690) will be included in ROMA:Women, increasing efficiency and reducing enrollment time.
Hypothesis 1.0. MAG will reduce the incidence of major adverse cardiac and cerebrovascular events.
Hypothesis 1.1. The improvement with MAG will be consistent across key subgroups.
Aim 2: Determine the impact of MAG vs SAG on generic and disease-specific QOL, physical and mental health symptoms in women undergoing CABG. The investigators will compare generic (SF-12, EQ-5D) and disease-specific (Seattle Angina Questionnaire) QOL and physical and mental health symptoms (PROMIS-29) in a sub-cohort of 500 women randomized 1:1 to MAG or SAG (including those enrolled in ROMA:QOL). Differences by important subgroups (as defined above) will also be evaluated.
Hypothesis 2.0. MAG will improve generic and disease-specific QOL compared to SAG.
Hypothesis 2.1. MAG will improve physical and mental health symptoms compared to SAG.
Hypothesis 2.2. The improvement with MAG will be consistent across key subgroups.
ROMA:Women will leverage the infrastructure and the existing women population of the ROMA trial. ROMA:Women has two key Aims. In Aim 1, the investigators will compare major adverse cardiac and cerebrovascular events (death, stroke, non-procedural myocardial infarction, repeat revascularization and hospital readmission for acute coronary syndrome or heart failure) in a cohort of 2,300 women randomized 1:1 to MAG or SAG. In Aim 2, the investigators will compare generic (SF-12, EQ-5D) and disease-specific (Seattle Angina Questionnaire) QOL and physical and mental health symptoms (PROMIS-29) in a sub-cohort of 500 women randomized 1:1 to MAG or SAG. Differences by important subgroups (patients younger or older than 70 years, diabetics, racial and ethnic minorities, on vs off pump CABG, type of arterial grafts used) will also be evaluated.
ROMA:Women is a two-arm, international, multi-center, randomized clinical trial nested in the ROMA trial. ROMA:Women will include all the women enrolled in the parent ROMA trial and will leverage the existing ROMA infrastructure including clinical trial unit, database, case report forms (CRF), randomization system, site training resources, informed consent forms (ICF), regulatory approvals, Central Events Review Committee (CEC) processes/personnel, network of participating sites, site PIs, and study coordinators. The planned randomization procedure, interventions and treatment arms, outcome assessments and follow-up protocol of ROMA:Women are identical to those of the currently ongoing parent ROMA trial. The sites participating in ROMA will continue enrollment of women after the completion of the ROMA trial and additional sites will also be opened to reach the target sample size of ROMA:Women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single Arterial Graft (SAG) group | Experimental | Patients in this group will receive a single arterial graft which will be the left internal thoracic artery. Additional grafts used in this group will all be venous grafts. |
|
| Multiple Arterial Graft (MAG) group | Experimental | Patients in the group will receive multiple arterial grafts. All patients will receive at least two arterial grafts, the left internal thoracic artery with the addition of either the right internal thoracic artery or the radial artery as the second conduit. Some patients may receive additional arterial grafts consisting of the radial artery, the right internal thoracic artery, or the right gastroepiploic artery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Single arterial graft | Procedure | This interventions consists of patients receiving the left internal thoracic artery to the left anterior descending coronary artery of the heart. In addition to the left internal thoracic artery patients will receive venous grafts for all additional grafting. |
| Measure | Description | Time Frame |
|---|---|---|
| Primary outcome for aim 1: Death from any cause, any stroke, non-procedural myocardial infarction, repeat revascularization and hospital readmission for acute coronary syndrome or heart failure. | The primary outcome for aim 1 will be a composite of the first occurrence of death from any cause, any stroke, non-procedural myocardial infarction (>48 hours after surgery), repeat revascularization and hospital readmission for acute coronary syndrome or heart failure. | Postoperatively, minimum 2.5 year follow-up |
| Primary outcome for aim 2: Disease-specific quality of life | Assessed using the Seattle Angina Questionnaire (SAQ), a validated 19-item questionnaire that measures five domains related to coronary disease: angina frequency, physical limitations, quality of life, angina stability, and treatment satisfaction. Scores range from 0 to 100 with higher scores indicating fewer symptoms and better health status. The minimum clinically important difference on the SAQ is 5 points. The primary endpoint for aim 2 is the absolute change in the Seattle Angina Questionnaire (SAQ) at 12 months compared to baseline. | Postoperatively, minimum 2.5 year follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Death from any cause, any stroke, non-procedural myocardial infarction, and repeat revascularization. | One of the secondary outcomes for aim 1: It will be a composite of the first occurrence of death from any cause, any stroke, non-procedural myocardial infarction (>48 hours after surgery), and repeat revascularization. This is the primary outcome of the parent ROMA trial. | Postoperatively, minimum 2.5 year follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Other recorded outcomes (safety endpoints) | 30-day mortality and major postoperative complications (revision for bleeding, perioperative MI (<48 hours after surgery), need for dialysis, need for tracheostomy, and surgical site complications). | Within 30 days of surgery or during index hospitalization, whichever is longer. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mario Gaudino, Prof/PhD/MD | Contact | 212.746.1812 | mfg9004@med.cornell.edu | |
| Stephen Fremes, Prof/MD | Contact | 1 416 480 6073 | stephen.fremes@sunnybrook.ca |
| Name | Affiliation | Role |
|---|---|---|
| Mario Gaudino, Prof/PhD/MD | Weill Medical College of Cornell University | Principal Investigator |
| Stephen Fremes, MD | Sunnybrook Health Sciences Centre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cedars-Sinai Medical Center | Recruiting | Los Angeles | California | 90048 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 3484393 | Background | Loop FD, Lytle BW, Cosgrove DM, Stewart RW, Goormastic M, Williams GW, Golding LA, Gill CC, Taylor PC, Sheldon WC, et al. Influence of the internal-mammary-artery graft on 10-year survival and other cardiac events. N Engl J Med. 1986 Jan 2;314(1):1-6. doi: 10.1056/NEJM198601023140101. | |
| 14726042 | Background | Tatoulis J, Buxton BF, Fuller JA. Patencies of 2127 arterial to coronary conduits over 15 years. Ann Thorac Surg. 2004 Jan;77(1):93-101. doi: 10.1016/s0003-4975(03)01331-6. |
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Primary outcome data under request
From publication until the third year after publication
Research scope
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| OTHER |
| Duke University | OTHER |
Patients undergoing coronary artery bypass surgery will be in one of two groups. One group will receive a single arterial graft and the second group will receive two or more arterial grafts.
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The endpoint assessors will be blinded to treatment allocation (PROBE).
|
| Multiple arterial grafting | Procedure | This intervention consists of the patient receiving the left internal thoracic artery to the left anterior descending coronary artery of the heart. The second arterial graft (right internal thoracic artery or radial artery) will be directed to the major branch of the circumflex. Additional grafts will include saphenous veins or arterial conduits. |
|
| Death from cardiac cause, any stroke, non-procedural myocardial infarction, repeat revascularization and hospital readmission for acute coronary syndrome or heart failure. | Another secondary outcome for aim 1: It will be a composite of the first occurrence of death from cardiac cause, any stroke, non-procedural myocardial infarction (>48 hours after surgery), repeat revascularization, and hospital readmission for acute coronary syndrome or heart failure. | Postoperatively, minimum 2.5 year follow-up |
| Death from any cause | Another secondary outcome for aim 1: Death will be considered to be cardiac unless a definite non-cardiac cause is identified. | Postoperatively, minimum 2.5 year follow-up |
| Stroke | Another secondary outcome for aim 1: Based on the American Heart Association/American Stroke Association Expert Consensus stroke definition, stroke will be identified in case of:
| Postoperatively, minimum 2.5 year follow-up |
| Non-procedural myocardial infarction | Another secondary outcome for aim 1: Based on the 4th Universal Definition, non-periprocedural myocardial infarction will be identified in case of detection of rise and/or fall of cardiac biomarkers with at least one value above the 99th percentile of the upper reference limit together with evidence of myocardial ischemia with at least one of the following:
| > 48 hours postoperatively, minimum 2.5 year follow-up |
| Repeat revascularization | Another secondary outcome for aim 1: Repeat revascularization will include any percutaneous or surgical revascularization on a grafted coronary artery after the initial operation. | Postoperatively, minimum 2.5 year follow-up |
| Readmission for acute coronary syndrome | Another secondary outcome for aim 1: Prolonged ischemic symptoms at rest (usually ≥10 minutes in duration), or accelerating pattern of chest pain that occurs with a lower activity threshold (CCS class III or IV) considered to be myocardial ischemia upon final diagnosis resulting in an unscheduled visit to a healthcare facility resulting in an overnight stay generally within 24 hours of the most recent symptoms, cardiac biomarkers not meeting MI criteria, and ECG or angiographic evidence of ischemia. | Postoperatively, minimum 2.5 year follow-up |
| Readmission for heart failure | Another secondary outcome for aim 1: While patients may have multiple simultaneous disease processes, for the outcome event of heart failure requiring hospitalization, the diagnosis of congestive heart failure would need to be the primary process. Heart failure (HF) requiring hospitalization is defined as an event that meets the following criteria: i. Requires hospitalization AND ii. Clinical symptoms of heart failure AND iii. Physical signs of heart failure AND iv. Need for additional/increased therapy AND v. No other non-cardiac etiology (such as chronic obstructive pulmonary disease, hepatic cirrhosis, acute renal failure, or venous insufficiency) and no other cardiac etiology (such as pulmonary embolus, cor pulmonale, primary pulmonary hypertension, or congenital heart disease) for signs or symptoms are identified. | Postoperatively, minimum 2.5 year follow-up |
| Generic quality of life according to the Short Form Health Survey (SF-12v2) | Secondary outcomes for aim 2: The SF-12v12 measures eight dimensions of health: physical functioning, role limitations due to physical problems, bodily pain, vitality, general health perception, social function, role limitations due to emotional problems, and mental health. Scores for each domain range from 0 to 100 with higher scores indicating better health status. The SF-12v2 has two summary measures: physical and mental self-perceived health with norm-based methods that standardize the score to a mean of 50 and standard deviation of 10. | Postoperatively, minimum 2.5 year follow-up |
| Generic quality of life according to EuroQuol-5D (EQ-5D) | Secondary outcomes for aim 2: EQ-5D is a five-item instrument to assess health status in the following five dimensions: mobility, self-care, usual activity, pain or discomfort, and anxiety or depression. Individual domain scores will be converted to a summary index representing utility weights, which allow conduct of cost-effectiveness analyses. | Postoperatively, minimum 2.5 year follow-up |
| Mental and physical health symptoms according to PROMIS instruments | Secondary outcomes for aim 2: Physical and mental health symptoms and physical functioning will be measured with standardized PROMIS instruments, including: Pain interference, Neuropathic Pain, Fatigue, Sleep disturbance, Depression, Anxiety, and Physical Function. A mean of 50 and a standard deviation of 10 represent the general population in the US. | Postoperatively, minimum 2.5 year follow-up |
| Ruth Masterson Creber, RN, PhD |
| Columbia University |
| Principal Investigator |
| C. Noel Bairey Merz, MD | Cedars-Sinai | Principal Investigator |
| Karla Ballman, PhD | Weill Medical College of Cornell University | Principal Investigator |
| Sean O'Brien, PhD | Duke University | Principal Investigator |
| Pomona Valley Hospital Medical Center | Recruiting | Pomona | California | 91767 | United States |
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| University of California, San Francisco | Recruiting | San Francisco | California | 94118 | United States |
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| University of Colorado | Recruiting | Aurora | Colorado | 80045 | United States |
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| Hartford Hospital | Recruiting | Hartford | Connecticut | 06106 | United States |
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| Yale University Hospital | Recruiting | New Haven | Connecticut | 06510 | United States |
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| Emory University | Recruiting | Atlanta | Georgia | 30322 | United States |
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| University of Chicago | Recruiting | Chicago | Illinois | 60637 | United States |
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| Indiana University | Recruiting | Indianapolis | Indiana | 46202 | United States |
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| University of Iowa | Recruiting | Iowa City | Iowa | 52242 | United States |
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| Johns Hopkins University | Recruiting | Baltimore | Maryland | 21218 | United States |
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| Baystate Health | Recruiting | Springfield | Massachusetts | 01199 | United States |
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| University of Massachusetts Chan Medical School | Completed | Worcester | Massachusetts | 01655 | United States |
| University of Michigan | Recruiting | Ann Arbor | Michigan | 48104 | United States |
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| Corewell Health William Beaumont University Hospital | Recruiting | Royal Oak | Michigan | 48073 | United States |
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| Washington University in St. Louis | Recruiting | St Louis | Missouri | 63110 | United States |
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| Nebraska Heart Hospital | Not yet recruiting | Lincoln | Nebraska | 68526 | United States |
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| Methodist Physicians Health | Recruiting | Omaha | Nebraska | 68118 | United States |
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| University of Nebraska Medical Center | Recruiting | Omaha | Nebraska | 68198 | United States |
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| Englewood Health | Recruiting | Englewood | New Jersey | 07631 | United States |
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| Newark Beth Israel Medical Center | Recruiting | Newark | New Jersey | 07112 | United States |
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| The Valley Hospital | Recruiting | Ridgewood | New Jersey | 07450 | United States |
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| NewYork-Presbyterian Brooklyn Methodist Hospital | Recruiting | Brooklyn | New York | 11215 | United States |
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| Weill Cornell Medicine | Recruiting | New York | New York | 10021 | United States |
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| Columbia University Medical Center | Recruiting | New York | New York | 10032 | United States |
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| Lenox Hill Hospital | Not yet recruiting | New York | New York | 10075 | United States |
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| New York Presbyterian Queens | Recruiting | Queens | New York | 11355 | United States |
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| Duke University | Recruiting | Durham | North Carolina | 27710 | United States |
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| East Carolina University | Recruiting | Greenville | North Carolina | 27858 | United States |
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| Wake Forest University | Recruiting | Winston-Salem | North Carolina | 27106 | United States |
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| Cleveland Clinic Foundation | Not yet recruiting | Cleveland | Ohio | 44195 | United States |
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| Ohio State University | Recruiting | Columbus | Ohio | 43210 | United States |
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| Genesis Healthcare System | Recruiting | Zanesville | Ohio | 43701 | United States |
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| University of Pennsylvania | Recruiting | Philadelphia | Pennsylvania | 19104 | United States |
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| Allegheny General Hospital | Not yet recruiting | Pittsburgh | Pennsylvania | 15212 | United States |
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| Lankenau Medical Center | Recruiting | Wynnewood | Pennsylvania | 19096 | United States |
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| Rhode Island Hospital | Recruiting | Providence | Rhode Island | 02903 | United States |
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| Baylor Scott & White Research Institute | Recruiting | Dallas | Texas | 75204 | United States |
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| The University of Texas Medical Health Branch at Galveston | Recruiting | Galveston | Texas | 77550 | United States |
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| Baylor College of Medicine | Recruiting | Houston | Texas | 77030 | United States |
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| UT Health San Antonio | Recruiting | San Antonio | Texas | 78229 | United States |
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| University of Utah | Recruiting | Salt Lake City | Utah | 84132 | United States |
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| Victorian Heart Hospital | Recruiting | Clayton | 3168 | Australia |
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| The University of Melbourne | Recruiting | Melbourne | Australia |
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| Medical University of Graz | Recruiting | Graz | 8010 | Austria |
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| Innsbruck Medical University | Recruiting | Innsbruck | 6020 | Austria |
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| Kepler University Hospital | Recruiting | Linz | Austria |
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| Medical University of Vienna | Recruiting | Vienna | 1090 | Austria |
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| Krankenhaus Nord Vienna North Hospital | Recruiting | Vienna | 1210 | Austria |
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| Institute of Cardiology Porto Alegre | Not yet recruiting | Porto Alegre | 9062000 | Brazil |
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| Heart Institute University of São Paulo | Recruiting | São Paulo | 05508 | Brazil |
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| Instituto Dante Pazzanese de Cardiologia | Not yet recruiting | Vila Mariana | 04012-909 | Brazil |
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| Mazankowski Alberta Heart Institute | Recruiting | Edmonton | Alberta | Canada |
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| St. Boniface General Hospital | Recruiting | Winnipeg | Manitoba | R2H 2A6 | Canada |
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| Horizon Health Network - Saint John Regional Hospital | Recruiting | Saint John | New Brunswick | E2L 4L2 | Canada |
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| Newfoundland and Labrador Health Services | Recruiting | St. John's | Newfoundland and Labrador | A1B 3R4 | Canada |
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| Health Sciences North | Recruiting | Greater Sudbury | Ontario | P3E 5J1 | Canada |
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| Hamilton General Hospital | Recruiting | Hamilton | Ontario | L8L 2X2 | Canada |
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| London Health Sciences | Recruiting | London | Ontario | N6A 5A5 | Canada |
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| University of Ottawa Heart Institute | Recruiting | Ottawa | Ontario | K1Y 4W7 | Canada |
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| Sunnybrook Health Sciences | Recruiting | Toronto | Ontario | M4N 3M5 | Canada |
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| Toronto General Hospital | Not yet recruiting | Toronto | Ontario | M5G 2C4 | Canada |
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| Montreal Heart Institute | Recruiting | Montreal | Quebec | H1T 1C8 | Canada |
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| University Hospital of Montreal | Recruiting | Montreal | Quebec | H2X 3E4 | Canada |
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| Royal Victoria Hospital | Recruiting | Montreal | Quebec | H4A 3J1 | Canada |
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| Institut Universitaire de Cardiologie et de Pneumologie de Québec | Recruiting | Ste Foy | Quebec | G1V 4G5 | Canada |
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| Hopital Sacre-Coeur | Recruiting | Montreal | Canada |
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| Fraser Clinical Trials | Recruiting | New Westminster | Canada |
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| Fuwai Hospital China | Completed | Beijing | Beijing Municipality | 100037 | China |
| Jilin Heart Hospital China | Completed | Changchun | Jilin | 130052 | China |
| Ruijin Hospital Shanghai Jiao Tong University School of Medicine | Completed | Shanghai | Shanghai Municipality | 200025 | China |
| Teda Hospital Tianjin China | Completed | Tianjin | Tianjin Municipality | 300456 | China |
| University Hospital Dubrava | Recruiting | Zagreb | 10000 | Croatia |
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| University Hradec Králové | Recruiting | Hradec Králové | 500 03 | Czechia |
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| General University Hospital, Prague | Not yet recruiting | New Town | 128 08 | Czechia |
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| Aalborg University Hospital | Recruiting | Aalborg | 9000 | Denmark |
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| Rigshospitalet | Recruiting | Copenhagen | 2100 | Denmark |
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| Universitäts-Herzzentrum Bad Krozingen Freiburg | Recruiting | Bad Krozingen | Baden-Wurttemberg | 79189 | Germany |
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| HDZ NRW Bad Oeynhausen Germany | Recruiting | Bad Oeynhausen | 32545 | Germany |
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| Deutsches Herzzentrum der Charite | Recruiting | Berlin | Germany |
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| Duisburg Heart Center | Not yet recruiting | Duisburg | 47137 | Germany |
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| Dusseldorf University | Recruiting | Düsseldorf | 40225 | Germany |
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| University Hospital Erlangen | Completed | Erlangen | 91054 | Germany |
| Essen University | Recruiting | Essen | 45147 | Germany |
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| Frankfurt University | Not yet recruiting | Frankfurt | 60323 | Germany |
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| University Hospital of Giessen and Marburg | Recruiting | Giessen | 35385 | Germany |
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| University Medical Center of Göttingen | Recruiting | Göttingen | 37075 | Germany |
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| Heidelberg University | Recruiting | Heidelberg | Germany |
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| Jena University Hospital | Recruiting | Jena | 07743 | Germany |
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| Heart Center Herzzentrum, Leipzig | Recruiting | Leipzig | 04289 | Germany |
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| TUM University Hospital German Heart Center | Recruiting | Munich | Germany |
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| Robert-Bosch-Hospital Stuttgart Germany | Not yet recruiting | Stuttgart | 70376 | Germany |
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| Krankenhaus der Barmherzigen Brüder Trier | Recruiting | Trier | 54292 | Germany |
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| G Kuppuswamy Naidu Memorial Hospital (GKNM) | Completed | Coimbatore | Tamil Nadu | 641037 | India |
| Star Hospitals - Hyderabad, India | Completed | Hyderabad | Telangana | 500034 | India |
| Rambam Health Care Campus | Completed | Haifa | 3109601 | Israel |
| Anthea Hospital | Recruiting | Bari | 70124 | Italy |
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| Humanitas Gavazzeni of Bergamo | Recruiting | Bergamo | 24125 | Italy |
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| Fondazione Poliambulanza | Not yet recruiting | Brescia | 25124 | Italy |
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| Maria Cecilia Hospital GVM | Not yet recruiting | Cotignola | 48033 | Italy |
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| Careggi University Hospital | Recruiting | Florence | 50134 | Italy |
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| European Hospital | Recruiting | Roma | 00149 | Italy |
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| Universita' Cattolica del Sacro Cuore | Recruiting | Roma | 00168 | Italy |
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| Ospedale Le Molinette, Torino | Not yet recruiting | Torino | 10126 | Italy |
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| Tokyo Medical and Dental University | Not yet recruiting | Bunkyō-Ku | Tokyo | 113-8510 | Japan |
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| Saitama Medical University Japan | Not yet recruiting | Saitama | 350-0451 | Japan |
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| Leiden University Medical Center | Recruiting | Leiden | South Holland | 2333 | Netherlands |
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| Erasmus Medical Center | Recruiting | Rotterdam | South Holland | 3015 | Netherlands |
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| Maastricht University Medical Centre | Recruiting | Maastricht | 6229 | Netherlands |
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| Acibadem-Sistina Hospital | Recruiting | Skopje | North Macedonia |
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| Medical University Gdansk | Recruiting | Gdansk | 80-210 | Poland |
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| Medical University of Silesia | Recruiting | Katowice | 40-055 | Poland |
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| Zbigniew Religa Lower Silesian Heart Disease Centre | Recruiting | Zabrze | 41-800 | Poland |
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| University Hospital Coimbra | Recruiting | Coimbra | 3004-561 | Portugal |
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| Centro Hospitalar Lisboa Ocidental | Not yet recruiting | Lisbon | 1300-598 | Portugal |
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| Centro Hospitalar e Universitário Sao Joao | Recruiting | Porto | 4200-072 | Portugal |
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| National Research Medical Center of the Russian Academy of Sciences - Tomsk, Russia | Completed | Tomsk | Russia |
| Dedinje Cardiovascular Institute | Recruiting | Belgrade | 11000 | Serbia |
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| National University of Singapore | Not yet recruiting | Singapore | 119077 | Singapore |
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| Severance Cardiovascular Hospital, Yonsei University College of Medicine | Not yet recruiting | Seoul | 03722 | South Korea |
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| Seoul National University Hospital | Recruiting | Seoul | South Korea |
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| Hospital Universitario del Vinalopo | Recruiting | Elche | Alicante | 03293 | Spain |
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| Hospital Clinic de Barcelona | Recruiting | Barcelona | 08036 | Spain |
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| Hospital Clinico de San Carlos | Recruiting | Madrid | Spain |
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| NavarraBiomed | Recruiting | Pamplona | Spain |
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| Sahlgrenska University Hospital | Recruiting | Gothenburg | Sweden |
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| Karonlinska University Hospital | Recruiting | Stockholm | 171 76 | Sweden |
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| National Taiwan University Hospital | Not yet recruiting | Zhongzheng | Taipei | 100229 | Taiwan |
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| Blackpool Teaching Hospitals NHS Trust | Recruiting | Blackpool | Lancashire | FY3 8NR | United Kingdom |
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| Oxford University Hospitals NHS Trust | Recruiting | Multiple Locations | Oxford | United Kingdom |
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| University Hospitals of North Midlands NHS Trust | Recruiting | Stoke-on-Trent | Staffordshire | ST4 6QG | United Kingdom |
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| Royal Papworth NHS Foundation Trust | Recruiting | Cambridge | CB2 0A | United Kingdom |
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| NHS Golden Jubilee | Recruiting | Clydebank | G81 4DY | United Kingdom |
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| The Royal Infirmary of Edinburgh | Recruiting | Edinburgh | EH16 4SA | United Kingdom |
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| Hull University Hospitals | Recruiting | Hull | United Kingdom |
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| University Hospitals of Leicester | Recruiting | Leicester | United Kingdom |
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| Liverpool Heart and Chest Hospital Foundation Trust | Recruiting | Liverpool | L14 3PE | United Kingdom |
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| Guy's and St Thomas' NHS Foundation Trust | Recruiting | London | SE1 7EH | United Kingdom |
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| Imperial College Healthcare NHS Trust | Recruiting | London | W2 1NY | United Kingdom |
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| Guy's and St Thomas' NHS Foundation Trust - St Thomas' Hospital | Recruiting | London | United Kingdom |
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| St George's University Hospitals | Recruiting | London | United Kingdom |
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| Manchester University NHS Trust | Recruiting | Manchester | M13 9WL | United Kingdom |
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| South Tees Hospitals NHS Trust | Recruiting | Middlesbrough | TS4 3BW | United Kingdom |
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| Sheffield Teaching Hospitals NHS Foundation Trust | Recruiting | Sheffield | S10 2SB | United Kingdom |
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| Mid and South Essex NHS Foundation Trust | Recruiting | Westcliff-on-Sea | United Kingdom |
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| Royal Wolverhampton NHS Trust | Recruiting | Wolverhampton | WV10 0QP | United Kingdom |
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| 10220677 | Background | Lytle BW, Blackstone EH, Loop FD, Houghtaling PL, Arnold JH, Akhrass R, McCarthy PM, Cosgrove DM. Two internal thoracic artery grafts are better than one. J Thorac Cardiovasc Surg. 1999 May;117(5):855-72. doi: 10.1016/S0022-5223(99)70365-X. |
| 11567701 | Background | Taggart DP, D'Amico R, Altman DG. Effect of arterial revascularisation on survival: a systematic review of studies comparing bilateral and single internal mammary arteries. Lancet. 2001 Sep 15;358(9285):870-5. doi: 10.1016/S0140-6736(01)06069-X. |
| 24916209 | Background | Yi G, Shine B, Rehman SM, Altman DG, Taggart DP. Effect of bilateral internal mammary artery grafts on long-term survival: a meta-analysis approach. Circulation. 2014 Aug 12;130(7):539-45. doi: 10.1161/CIRCULATIONAHA.113.004255. Epub 2014 Jun 10. |
| 22070836 | Background | Hillis LD, Smith PK, Anderson JL, Bittl JA, Bridges CR, Byrne JG, Cigarroa JE, Disesa VJ, Hiratzka LF, Hutter AM Jr, Jessen ME, Keeley EC, Lahey SJ, Lange RA, London MJ, Mack MJ, Patel MR, Puskas JD, Sabik JF, Selnes O, Shahian DM, Trost JC, Winniford MD; American College of Cardiology Foundation; American Heart Association Task Force on Practice Guidelines; American Association for Thoracic Surgery; Society of Cardiovascular Anesthesiologists; Society of Thoracic Surgeons. 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Developed in collaboration with the American Association for Thoracic Surgery, Society of Cardiovascular Anesthesiologists, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2011 Dec 6;58(24):e123-210. doi: 10.1016/j.jacc.2011.08.009. Epub 2011 Nov 7. No abstract available. |
| 25173339 | Background | Authors/Task Force members; Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, Falk V, Filippatos G, Hamm C, Head SJ, Juni P, Kappetein AP, Kastrati A, Knuuti J, Landmesser U, Laufer G, Neumann FJ, Richter DJ, Schauerte P, Sousa Uva M, Stefanini GG, Taggart DP, Torracca L, Valgimigli M, Wijns W, Witkowski A. 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 2014 Oct 1;35(37):2541-619. doi: 10.1093/eurheartj/ehu278. Epub 2014 Aug 29. No abstract available. |
| 26680310 | Background | Aldea GS, Bakaeen FG, Pal J, Fremes S, Head SJ, Sabik J, Rosengart T, Kappetein AP, Thourani VH, Firestone S, Mitchell JD; Society of Thoracic Surgeons. The Society of Thoracic Surgeons Clinical Practice Guidelines on Arterial Conduits for Coronary Artery Bypass Grafting. Ann Thorac Surg. 2016 Feb;101(2):801-9. doi: 10.1016/j.athoracsur.2015.09.100. Epub 2015 Dec 8. |
| 24686003 | Background | Benedetto U, Raja SG, Albanese A, Amrani M, Biondi-Zoccai G, Frati G. Searching for the second best graft for coronary artery bypass surgery: a network meta-analysis of randomized controlled trialsdagger. Eur J Cardiothorac Surg. 2015 Jan;47(1):59-65; discussion 65. doi: 10.1093/ejcts/ezu111. Epub 2014 Mar 30. |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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