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| Name | Class |
|---|---|
| Bhumirajanagarindra Kidney Institute, Thailand | OTHER |
| Ministry of Health, Thailand | OTHER_GOV |
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On-line hemodiafiltration (HDF) clears more azotaemic toxins compared to high-flux hemodialysis (HD). The response to vaccination is impaired in dialysis patients. We aimed to study the immune responses to influenza vaccine in dialysis patients treated by HDF vs. HD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hemodialysis | Active Comparator | ESRD patients treated by hemodialysis |
|
| Hemodiafiltration | Active Comparator | ESRD patients treated by on-line hemodiafiltration |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Influenza vaccine | Biological | A single standard dose of inactivated trivalent influenza vaccine: Influvac® vaccines (Abbott, the Netherlands), intramuscularly. |
|
| Measure | Description | Time Frame |
|---|---|---|
| measurement antibody titers, determined by hemagglutination inhibition (HI) assay. | measurement antibody titers, determined by hemagglutination inhibition (HI) assay. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| measurement T cell subpopulations, determined by flow cytometer AND cell proliferation assay after stimulated with influenza viruses. | measurement T cell subpopulations, determined by flow cytometer AND cell proliferation assay after stimulated with influenza viruses. | 12 months |
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Inclusion Criteria:
- ESRD patients aged 18 years or older, who had been treated for more than one month of either thrice weekly on-line hemodiafiltration (HDF) or conventional high flux hemodialysis (HD), with a session dialyzer urea clearance (Kt/V urea) of 1.2 and greater, with a convection volume target of 20 L/session for the HDF group
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 7922228 | Result | Descamps-Latscha B. The immune system in end-stage renal disease. Curr Opin Nephrol Hypertens. 1993 Nov;2(6):883-91. doi: 10.1097/00041552-199311000-00005. | |
| 18552253 | Result | Hauser AB, Stinghen AE, Kato S, Bucharles S, Aita C, Yuzawa Y, Pecoits-Filho R. Characteristics and causes of immune dysfunction related to uremia and dialysis. Perit Dial Int. 2008 Jun;28 Suppl 3:S183-7. |
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International journal involving immunology and/or nephrology
6 months
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| ID | Term |
|---|---|
| D007676 | Kidney Failure, Chronic |
| D007251 | Influenza, Human |
| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
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| ID | Term |
|---|---|
| D007252 | Influenza Vaccines |
| ID | Term |
|---|---|
| D014765 | Viral Vaccines |
| D014612 | Vaccines |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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Open label
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|
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| 32012159 | Derived | Nongnuch A, Ngampongpan W, Srichatrapimuk S, Wongsa A, Thongpraphai S, Boonarkart C, Sanmeema N, Chittaganpitch M, Auewarakul P, Tassaneetrithep B, Davenport A, Phuphuakrat A. Immune response to influenza vaccination in ESRD patients undergoing hemodialysis vs. hemodiafiltration. PLoS One. 2020 Feb 3;15(2):e0227719. doi: 10.1371/journal.pone.0227719. eCollection 2020. |
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D009976 | Orthomyxoviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012140 | Respiratory Tract Diseases |