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roxithormycin 300 mg per day for 12 weeks could improve quality of life and physiological outcomes in bronchiectasis
A randomized, double blinded, placebo controlled study was conducted to evaluate the effects of a 12-week administration of roxithromycin 300 mg once daily and a 12-week follow-up period in symptomatic stable bronchiectasis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| roxithromycin | Active Comparator | roxithromycin 300 mg oral per day |
|
| placebo | Placebo Comparator | placebo one tablet per day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Roxithromycin 300 MG | Drug | Roxithromycin 300 mg oral per day |
|
| Measure | Description | Time Frame |
|---|---|---|
| SGRQ scores | SGRQ scores | for 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| pulmonary function tests | FEV1 | 24 weeks |
| sputum volumes | sputum volume per day | 24 wekse |
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minimum 15 year maximum 75 years
Criteria inclusion Criteria:
Symptomatic bronchiectasis Stable clinical bronchiectasis
Exclusion Criteria:
Adverse drug reaction to macrolide Recent exacerbation within 2 weeks History of macrolide therapy within 2 weeks active malignancy and end stage diseases 5. not perform lung function tests Females who were lactating
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| Name | Affiliation | Role |
|---|---|---|
| Kanung Saejiam, MS | Prince of Songkla University | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10445614 | Background | Nakamura H, Fujishima S, Inoue T, Ohkubo Y, Soejima K, Waki Y, Mori M, Urano T, Sakamaki F, Tasaka S, Ishizaka A, Kanazawa M, Yamaguchi K. Clinical and immunoregulatory effects of roxithromycin therapy for chronic respiratory tract infection. Eur Respir J. 1999 Jun;13(6):1371-9. doi: 10.1183/09031936.99.13613809. |
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| ID | Term |
|---|---|
| D001987 | Bronchiectasis |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D015575 | Roxithromycin |
| ID | Term |
|---|---|
| D004917 | Erythromycin |
| D018942 | Macrolides |
| D061065 | Polyketides |
| D007783 | Lactones |
| D009930 |
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randomised control study
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block of 4
| Placebo | Drug | Placebo one table oral once dialy |
|
| Organic Chemicals |