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Due to difficulties in obtaining consent because of emergency situation
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| Name | Class |
|---|---|
| Unimedics (http://unimedics.co.kr) | UNKNOWN |
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In trauma patients with high shock index, the investigators compare the effects on hemodynamics between ketamine and etomidate.
In trauma patients, rapid sequence intubation is recommended. The drug of choice, however, has been debated. One cohort comparative study showed ketamine had benefit in hemodynamics compared to etomidate in trauma patients. One observational study showed in high shock index patients, ketamine showed maintain systolic blood pressure. And other retrospective showed less clinical hypotension was less in ketamine. However there is no randomized controlled study comparing ketamine and etomidate in trauma patients. The purpose of this study is comparing the effects of hemodynamics between ketamine and etomidate in high shock index trauma patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Etomidate | Active Comparator | The induction agent of rapid sequence intubation is etomidate. 0.2 mg/kg |
|
| Ketamine | Experimental | The induction agent of rapid sequence intubation is ketamine. 2 mg/kg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Etomidate Injection 0.2 mg/kg | Drug | The induction agent of rapid sequence intubation is etomidate. 0.2 mg/kg |
|
| Measure | Description | Time Frame |
|---|---|---|
| Systolic blood pressure difference compared with baseline after 10 minutes | Systolic blood pressure 10 minutes after induction agent injection - baseline systolic blood pressure mmHg Positive or zero value means good result. Negative value means poor result. | 13 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Intubating condition | Intubator judge intubating condition Laryngoscopy: easy / fair / difficult (difficult is the worst result) Vocal cords position: abducted / moving / closed (closed is the worst result) Reaction to insertion of the tracheal tube and cuff inflation : none / slight / vigorous (none is the worst result) If one of category checked the worst score, it considered :clinically unacceptable". |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| In Kyong Yi, MD | Ajou University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ajou university school of medicine | Suwon | Gyeonggi-do | 16499 | South Korea |
If there is a reasonable request, we can share the data personally.
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| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D012774 | Shock, Traumatic |
| ID | Term |
|---|---|
| D012769 | Shock |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D005045 | Etomidate |
| D007649 | Ketamine |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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ketamine group: ketamine 2 mg/kg iv as induction agent etomidate group: etomidate 0.2 mg/kg iv as induction agent
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open label
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| Ketamine injection 2 mg/kg | Drug | The induction agent of rapid sequence intubation is ketamine. 2 mg/kg |
|
|
| 5 minutes |
| Incidence of hypotension | If any of these are checked, define as hypotension (from injection of induction agent to 20 minutes after)
Patient numbers (%) | 25 minutes |
| Incidence of hypertension | From injection of induction agent to 20 minutes after, systolic pressure > 160 mmHg defined as hypertension Patients numbers (%) | 25 miinutes |
| D003510 |
| Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |