Comparison of Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients

Comparison of Effects on Hemodynamics Between Ketamine and Etomidate During Rapid Sequence Intubation in Trauma Patients With High Shock Index

In trauma patients with high shock index, the investigators compare the effects on hemodynamics between ketamine and etomidate.

In trauma patients, rapid sequence intubation is recommended. The drug of choice, however, has been debated. One cohort comparative study showed ketamine had benefit in hemodynamics compared to etomidate in trauma patients. One observational study showed in high shock index patients, ketamine showed maintain systolic blood pressure. And other retrospective showed less clinical hypotension was less in ketamine. However there is no randomized controlled study comparing ketamine and etomidate in trauma patients. The purpose of this study is comparing the effects of hemodynamics between ketamine and etomidate in high shock index trauma patients.

Inclusion Criteria:

• age 19~70
• Shock index ≥ 0.9
• Patients who need intubation regarding to Ajou trauma center protocol

Exclusion Criteria:

• during CPR
• CPR before hospital arrival
• Severe head trauma
• Steroid intake history