Vitamin D3 in Sensory Recovery After Digital NERVe Suture (D3NERV).

Vitamin D3 in Sensory Recovery After Digital NERVe Suture: a Randomized Controlled Trial.

Digital nerve injuries are frequent in a FESUM center (Federation Européenne des Services d'Urgences Mains), and they need to be repaired in order to reduce the risk of hypoesthesia and to prevent painful neuroma. Several animal studies have shown that Cholecalciferol improves axonal nerve regeneration and myelination. No study has ever been done on human subjects to evaluate the nerve regeneration after Cholecalciferol supplementation.

Our hypothesis is that Cholecalciferol supplementation could improve axonal nerve regeneration and myelination after traumatic digital nerve injuries treated by microsurgical sutures and reduce the risk of hypoesthesia and neuroma.

Inclusion Criteria:

• Affiliated to social security scheme,
• Wound of the palmar hand with isolated digital nerve section, requiring digital nerve microsurgical suture in the operating room by a senior surgeon,
• Signing a free and informed consent and well-informed of the study and procedure.

Exclusion Criteria:

• Ischemia,
• Multiple lesion of the same nerve,
• Pregnant or nursing women,
• Contraindication of Cholecalciferol : known hypersensitivity, any history of hypercalcemia, hypercalciuria or renal lithiasis,
• Cholecalciferol supplementation in the past 6 months,
• Lesion of the same controlateral finger,
• History of nerve lesion or hypoesthesia on the same finger,
• History of previous neurological disorders with upper limb sensitivity disorder,
• Impossibility to undergo the medical follow-up because of geographical, social or psychological reason,
• Participation in another clinical trial that does not allow simultaneous participation in several clinical trials,
• Orlistat® Treatment,
• History of celiac disease.