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Pulmonary vascular disease and cardiac performance in extreme preterm infants: A prospective cross-sectional study
The principal investigator hypothesize that premature newborns have disturbed cardiac performance and increased pulmonary pressures during neonatal life and at different pediatric ages.
The principal investigator also hypothesize that premature newborns with poor cardiac performance and/or pulmonary hypertension have higher morbidities and poorer neuro-developmental outcomes.
The principal investigator also hypothesize that premature newborns with poor cardiac performance and/or pulmonary hypertension have higher morbidities and poorer neuro-developmental outcomes and that novel echocardiography techniques will detect anomalies not uncovered by conventional imaging, and that early echocardiography may identify those with later pulmonary hypertension.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Neonatal profile | Echocardiography at:
|
| |
| Infant profile ( between 4 months and 9 months) |
|
| |
| Pediatric profile (36 months and 5 years) |
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Echocardiography | Other | Diagnostic test which uses ultrasound waves to make images of the heart chambers, valves and surrounding structures |
|
| Measure | Description | Time Frame |
|---|---|---|
| Heart function by echocardiography | STE allows for calculation of strain (absolute deformation) of segmental areas of the heart to provide insight on cardiac performance | 7-10 days of chronological age |
| Heart function by echocardiography | STE allows for calculation of strain (absolute deformation) of segmental areas of the heart to provide insight on cardiac performance | 35-37 weeks post-menstrual age |
| Heart function by echocardiography | STE allows for calculation of strain (absolute deformation) of segmental areas of the heart to provide insight on cardiac performance | 39-44 weeks PMA |
| Heart function by echocardiography | STE allows for calculation of strain (absolute deformation) of segmental areas of the heart to provide insight on cardiac performance | 4 months PMA |
| Heart function by echocardiography | STE allows for calculation of strain (absolute deformation) of segmental areas of the heart to provide insight on cardiac performance | 9 months PMA |
| Heart function by echocardiography | STE allows for calculation of strain (absolute deformation) of segmental areas of the heart to provide insight on cardiac performance | 36 months PMA |
| Heart function by echocardiography | STE allows for calculation of strain (absolute deformation) of segmental areas of the heart to provide insight on cardiac performance |
| Measure | Description | Time Frame |
|---|---|---|
| Neuro-developmental profile | Neuro-developmental profile of these patients at individual time points and put this profile in context of their cardiac performance by echocardiography | 7-10 days of chronological age |
| Neuro-developmental profile |
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Inclusion Criteria:
Exclusion Criteria:
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Extreme premature newborns (<29 weeks)
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mcgill University Health Centre | Recruiting | Montreal | Quebec | H4A 3J1 | Canada |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| 5 years chronological |
Neuro-developmental profile of these patients at individual time points and put this profile in context of their cardiac performance by echocardiography
| 35-37 weeks post-menstrual age |
| Neuro-developmental profile | Neuro-developmental profile of these patients at individual time points and put this profile in context of their cardiac performance by echocardiography | 39-44 weeks PMA |
| Neuro-developmental profile | Neuro-developmental profile of these patients at individual time points and put this profile in context of their cardiac performance by echocardiography | 4 months PMA |
| Neuro-developmental profile | Neuro-developmental profile of these patients at individual time points and put this profile in context of their cardiac performance by echocardiography | 9 months PMA |
| Neuro-developmental profile | Neuro-developmental profile of these patients at individual time points and put this profile in context of their cardiac performance by echocardiography | 36 months PMA |
| Neuro-developmental profile | Neuro-developmental profile of these patients at individual time points and put this profile in context of their cardiac performance by echocardiography | 5 years chronological |
| D000091642 | Urogenital Diseases |