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The purpose of this study is to determine whether outcomes for patients receiving intra-articular platelet-rich plasma (PRP) injections for knee osteoarthritis are influenced by observation of the preparatory steps to the procedure. The viewing of the steps involved in the administration of PRP may increase the effectiveness of the treatment in comparison to patients who have not observed the preparatory steps.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Viewing of preparation | Experimental | The patient will be in the room for the preparation of the PRP and will receive a description of the centrifuge process from the physician administering the injection. |
|
| Blinded to preparation | Sham Comparator | The patient will leave the room after their blood is drawn and will not view the preparation of the PRP, and will also not receive a description of the centrifuge process. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Platelet-rich plasma (PRP) | Biological | Autologous platelet-rich plasma which will be derived from blood drawn from the patient. |
|
| Measure | Description | Time Frame |
|---|---|---|
| VAS Pain | Visual analog scale pain on a 0-10 scale, with higher scores indicating worse pain. | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) | Patient reported knee osteoarthritis index with subscores of pain, function and stiffness. The range of scores on the WOMAC is from 0-96, with higher scores indicating worse outcomes. The subscore of pain is on a scale of 0-20, the subscore of stiffness is 0-8, and the subscale of function is 0-68. The scores of the subscales are summed in order to get the total score. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Moin Khan, FRCSC | McMaster University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ArthroBiologix | Hamilton | Ontario | Canada |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| Viewing of preparation | Behavioral | The patient will receive a description of the preparation process and will view the preparation in the centrifuge. |
|
| 12 weeks |
| Range of motion | Range of motion in the knee from full extension to full flexion. | 12 weeks |
| Short Form 12 (SF-12) Functional outcome assessment | Health-related quality of life measure on a scale from 0-100, where higher scores indicate better function. | 12 weeks |
| D012216 |
| Rheumatic Diseases |