Daxor - Blood Volume Analysis

Blood Volume Analysis - Guided Heart Failure Management

The purpose of this study is to better understand blood volume status and whether knowledge of it can change and improve heart failure care.

The purpose of this study is to better understand measurements of various parameters of congestion, the most significant of which is blood volume analysis. Blood volume analysis (BVA) measures how much blood is in the investigator's arteries and veins and is performed by using an IV and injecting a small amount of a radioactive material (I 131-labeled albumin). The study also involves blood tests, urine tests, blood pressure monitoring, an ultrasound, and measurement of lung fluid volume (by way of a vest). There will also be a 30-day follow-up phone call to assess symptoms and discuss any changes in medication.

Inclusion Criteria:

- Admission for acute decompensated heart failure to the cardiology service at Duke Hospital, Durham, North Carolina

Exclusion Criteria:

• Age < 18 years
• Ongoing pregnancy
• Recent acute MI or hemodynamic instability: Acute MI (STEMI or Type I NSTEMI) within 7 days
• Post heart transplantation or ongoing mechanical circulatory support
• Progressive cardiogenic shock
• Patients with Ventricular Assist Devices
• End stage renal disease