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This project will study the effect of oxytocin on hemodynamics in patients undergoing laparoscopic myomectomy, and how to prevent and manage such hemodynamic changes effectively.It provides a reference for the rational use of oxytocin in clinical practice, which can not only effectively contract the uterus and reduce bleeding, but also reduce the influence on hemodynamics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group 1 with no oxytocin | No Intervention | ||
| group 2 with oxytocin 10 U IM + oxytocin 10 U IV | Experimental |
| |
| group 3 with oxytocin 20 U IM + oxytocin 0 U IV | Experimental |
| |
| group 4 with oxytocin 0 U IM + oxytocin 20 U IV | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxytocin | Drug | During the laparoscopic hysteromyomectomia operation, different doses of oxytocin was used with different routs. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes of traditional hemodynamic parameters after oxytocin use during laparoscopic hysteromyomectomia. | Parameters including SBP, DBP, MAP (mmHg) were measured by a Mostcare hemodynamic monitor. | "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection". |
| Changes of traditional hemodynamic parameters after oxytocin use during laparoscopic hysteromyomectomia. | HR (beats/min) was measured by a Mostcare hemodynamic monitor. | "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection". |
| Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia. | SVV (%) was measured by a Mostcare hemodynamic monitor. | "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection". |
| Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia. | SVRI (dynes-sec/cm-5) was measured by a Mostcare hemodynamic monitor. | "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection". |
| Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia. | CI (l/min/m2) was measured by a Mostcare hemodynamic monitor. | "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection". |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhuan Zhang | Contact | +8615062791355 | +8615062791355 | zhangzhuanjy@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the Affiliated Hospital of Yangzhou University | Recruiting | Yangzhou | Jiangsu | 225012 | China |
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| ID | Term |
|---|---|
| D010121 | Oxytocin |
| ID | Term |
|---|---|
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia. | CO (l/min) was measured by a Mostcare hemodynamic monitor. | "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection". |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |