The Psoriatic Arthritis Disease Activity Score ranges from 0-10; higher scores represent a worse outcome.

The Composite Psoriatic Disease Activity Index ranges from 0-15; higher scores represent a worse outcome.

The Composite Psoriatic Disease Activity Index ranges from 0-15; higher scores represent a worse outcome.

The Composite Psoriatic Disease Activity Index ranges from 0-15; higher scores represent a worse outcome.

The Composite Psoriatic Disease Activity Index ranges from 0-15; higher scores represent a worse outcome.

The Participant Disease Activity Visual Analogue Score ranges from 0-100; higher scores represent a worse outcome.

The Participant Disease Activity Visual Analogue Score ranges from 0-100; higher scores represent a worse outcome.

The 36-item Short Form Health Survey (SF-36) Physical Component Score ranges from 0-100; higher scores represent a better outcome.

The 36-item Short Form Health Survey (SF-36) Physical Component Score ranges from 0-100; higher scores represent a better outcome.

The 36-item Short Form Health Survey (SF-36) Mental Component Score ranges from 0-100; higher scores represent a better outcome.

The 36-item Short Form Health Survey (SF-36) Mental Component Score ranges from 0-100; higher scores represent a better outcome.

In the joint set scanned in the Full Analysis Set, the Ultrasound Global OMERACT-EULAR System Score ranged from 0-72; higher scores represent a worse outcome.

In the joint set scanned in the Full Analysis Set, the Ultrasound Global OMERACT-EULAR System Score ranged from 0-72; higher scores represent a worse outcome.

In the joint set scanned in the Full Analysis Set, the Ultrasound Global OMERACT-EULAR System Score ranged from 0-72; higher scores represent a worse outcome.

The Ultrasound Entheseal Inflammatory Score ranged from 0-70; a higher score represents a worse outcome.

The Ultrasound Entheseal Inflammatory Score ranged from 0-70; a higher score represents a worse outcome.

The Ultrasound Entheseal Inflammatory Score ranged from 0-70; a higher score represents a worse outcome.

The Ultrasound Entheseal Chronicity Score ranged from 0-50; a higher score represents a worse outcome.

The Ultrasound Entheseal Chronicity Score ranged from 0-50; a higher score represents a worse outcome.

The Ultrasound Entheseal Chronicity Score ranged from 0-50; a higher score represents a worse outcome.

The Leeds Enthesitis Index ranges from 0-6; a higher score represents a worse outcome.

The Leeds Enthesitis Index ranges from 0-6; a higher score represents a worse outcome.

The Leeds Enthesitis Index ranges from 0-6; a higher score represents a worse outcome.

The Leeds Enthesitis Index ranges from 0-6; a higher score represents a worse outcome.

The Leeds Dactylitis Index ranges from 0-~40; a higher score represents a worse outcome.

The Leeds Dactylitis Index ranges from 0-~40; a higher score represents a worse outcome.

The Leeds Dactylitis Index ranges from 0-~40; a higher score represents a worse outcome.

The Leeds Dactylitis Index ranges from 0-~40; a higher score represents a worse outcome.

The Modified Nail Psoriasis Severity Index ranges from 0-140; a higher score represents a worse outcome.

The Modified Nail Psoriasis Severity Index ranges from 0-140; a higher score represents a worse outcome.

The Modified Nail Psoriasis Severity Index ranges from 0-140; a higher score represents a worse outcome.

The Modified Nail Psoriasis Severity Index ranges from 0-140; a higher score represents a worse outcome.

The Psoriasis Area and Severity Index ranges from 0-72; a higher score represents a worse outcome.

The Psoriasis Area and Severity Index ranges from 0-72; a higher score represents a worse outcome.

The Psoriasis Area and Severity Index ranges from 0-72; a higher score represents a worse outcome.

The Psoriasis Area and Severity Index ranges from 0-72; a higher score represents a worse outcome.

The Dermatology Life Quality Index ranges from 0-30; a higher score represents a worse outcome.

The Dermatology Life Quality Index ranges from 0-30; a higher score represents a worse outcome.

Minimal Disease Activity (coded 0=No, 1=Yes) is achieved when at least 5 of the 7 following criteria are met: Tender joint count (/68) ≤1 Swollen joint count (/66) ≤1 PASI ≤1 or BSA≤3 Patient pain VAS ≤15 Patient global disease activity VAS ≤20 HAQ ≤0.5 Enthesitis count ≤1.

Minimal Disease Activity (coded 0=No, 1=Yes) is achieved when at least 5 of the 7 following criteria are met: Tender joint count (/68) ≤1 Swollen joint count (/66) ≤1 PASI ≤1 or BSA≤3 Patient pain VAS ≤15 Patient global disease activity VAS ≤20 HAQ ≤0.5 Enthesitis count ≤1.

Minimal Disease Activity (coded 0=No, 1=Yes) is achieved when at least 5 of the 7 following criteria are met: Tender joint count (/68) ≤1 Swollen joint count (/66) ≤1 PASI ≤1 or BSA≤3 Patient pain VAS ≤15 Patient global disease activity VAS ≤20 HAQ ≤0.5 Enthesitis count ≤1.

Minimal Disease Activity (coded 0=No, 1=Yes) is achieved when at least 5 of the 7 following criteria are met: Tender joint count (/68) ≤1 Swollen joint count (/66) ≤1 PASI ≤1 or BSA≤3 Patient pain VAS ≤15 Patient global disease activity VAS ≤20 HAQ ≤0.5 Enthesitis count ≤1.

American College of Rheumatology 20 Response (coded 0=No, 1=Yes) is achieved when there is:

• 20% improvement in both TJC (68 joints count) and SJC (66 joints count) and

• 20% improvement in at least 3 of the following 5 ACR Core set criteria:

  1. Patient's Assessment of Pain Visual Analogue Scale (VAS)
  2. Patient's Global Assessment of Disease Activity VAS
  3. Physician's Global Assessment of Disease Activity VAS
  4. Patient's Assessment of Physical Function as measured by the HAQ-DI
  5. Acute phase reactant as measured by CRP

American College of Rheumatology 20 Response (coded 0=No, 1=Yes) is achieved when there is:

• 20% improvement in both TJC (68 joints count) and SJC (66 joints count) and

• 20% improvement in at least 3 of the following 5 ACR Core set criteria:

  1. Patient's Assessment of Pain Visual Analogue Scale (VAS)
  2. Patient's Global Assessment of Disease Activity VAS
  3. Physician's Global Assessment of Disease Activity VAS
  4. Patient's Assessment of Physical Function as measured by the HAQ-DI
  5. Acute phase reactant as measured by CRP

American College of Rheumatology 20 Response (coded 0=No, 1=Yes) is achieved when there is:

• 20% improvement in both TJC (68 joints count) and SJC (66 joints count) and

• 20% improvement in at least 3 of the following 5 ACR Core set criteria:

  1. Patient's Assessment of Pain Visual Analogue Scale (VAS)
  2. Patient's Global Assessment of Disease Activity VAS
  3. Physician's Global Assessment of Disease Activity VAS
  4. Patient's Assessment of Physical Function as measured by the HAQ-DI
  5. Acute phase reactant as measured by CRP

American College of Rheumatology 20 Response (coded 0=No, 1=Yes) is achieved when there is:

• 20% improvement in both TJC (68 joints count) and SJC (66 joints count) and

• 20% improvement in at least 3 of the following 5 ACR Core set criteria:

  1. Patient's Assessment of Pain Visual Analogue Scale (VAS)
  2. Patient's Global Assessment of Disease Activity VAS
  3. Physician's Global Assessment of Disease Activity VAS
  4. Patient's Assessment of Physical Function as measured by the HAQ-DI
  5. Acute phase reactant as measured by CRP

American College of Rheumatology 50 Response (coded 0=No, 1=Yes) is achieved when there is:

• 50% improvement in both TJC (68 joints count) and SJC (66 joints count) and

• 50% improvement in at least 3 of the following 5 ACR Core set criteria:

  1. Patient's Assessment of Pain Visual Analogue Scale (VAS)
  2. Patient's Global Assessment of Disease Activity VAS
  3. Physician's Global Assessment of Disease Activity VAS
  4. Patient's Assessment of Physical Function as measured by the HAQ-DI
  5. Acute phase reactant as measured by CRP

American College of Rheumatology 50 Response (coded 0=No, 1=Yes) is achieved when there is:

• 50% improvement in both TJC (68 joints count) and SJC (66 joints count) and

• 50% improvement in at least 3 of the following 5 ACR Core set criteria:

  1. Patient's Assessment of Pain Visual Analogue Scale (VAS)
  2. Patient's Global Assessment of Disease Activity VAS
  3. Physician's Global Assessment of Disease Activity VAS
  4. Patient's Assessment of Physical Function as measured by the HAQ-DI
  5. Acute phase reactant as measured by CRP

American College of Rheumatology 50 Response (coded 0=No, 1=Yes) is achieved when there is:

• 50% improvement in both TJC (68 joints count) and SJC (66 joints count) and

• 50% improvement in at least 3 of the following 5 ACR Core set criteria:

  1. Patient's Assessment of Pain Visual Analogue Scale (VAS)
  2. Patient's Global Assessment of Disease Activity VAS
  3. Physician's Global Assessment of Disease Activity VAS
  4. Patient's Assessment of Physical Function as measured by the HAQ-DI
  5. Acute phase reactant as measured by CRP

American College of Rheumatology 50 Response (coded 0=No, 1=Yes) is achieved when there is:

• 50% improvement in both TJC (68 joints count) and SJC (66 joints count) and

• 50% improvement in at least 3 of the following 5 ACR Core set criteria:

  1. Patient's Assessment of Pain Visual Analogue Scale (VAS)
  2. Patient's Global Assessment of Disease Activity VAS
  3. Physician's Global Assessment of Disease Activity VAS
  4. Patient's Assessment of Physical Function as measured by the HAQ-DI
  5. Acute phase reactant as measured by CRP

American College of Rheumatology 70 Response (coded 0=No, 1=Yes) is achieved when there is:

• 70% improvement in both TJC (68 joints count) and SJC (66 joints count) and

• 70% improvement in at least 3 of the following 5 ACR Core set criteria:

  1. Patient's Assessment of Pain Visual Analogue Scale (VAS)
  2. Patient's Global Assessment of Disease Activity VAS
  3. Physician's Global Assessment of Disease Activity VAS
  4. Patient's Assessment of Physical Function as measured by the HAQ-DI
  5. Acute phase reactant as measured by CRP

American College of Rheumatology 70 Response (coded 0=No, 1=Yes) is achieved when there is:

• 70% improvement in both TJC (68 joints count) and SJC (66 joints count) and

• 70% improvement in at least 3 of the following 5 ACR Core set criteria:

  1. Patient's Assessment of Pain Visual Analogue Scale (VAS)
  2. Patient's Global Assessment of Disease Activity VAS
  3. Physician's Global Assessment of Disease Activity VAS
  4. Patient's Assessment of Physical Function as measured by the HAQ-DI
  5. Acute phase reactant as measured by CRP

American College of Rheumatology 70 Response (coded 0=No, 1=Yes) is achieved when there is:

• 70% improvement in both TJC (68 joints count) and SJC (66 joints count) and

• 70% improvement in at least 3 of the following 5 ACR Core set criteria:

  1. Patient's Assessment of Pain Visual Analogue Scale (VAS)
  2. Patient's Global Assessment of Disease Activity VAS
  3. Physician's Global Assessment of Disease Activity VAS
  4. Patient's Assessment of Physical Function as measured by the HAQ-DI
  5. Acute phase reactant as measured by CRP

American College of Rheumatology 70 Response (coded 0=No, 1=Yes) is achieved when there is:

• 70% improvement in both TJC (68 joints count) and SJC (66 joints count) and

• 70% improvement in at least 3 of the following 5 ACR Core set criteria:

  1. Patient's Assessment of Pain Visual Analogue Scale (VAS)
  2. Patient's Global Assessment of Disease Activity VAS
  3. Physician's Global Assessment of Disease Activity VAS
  4. Patient's Assessment of Physical Function as measured by the HAQ-DI
  5. Acute phase reactant as measured by CRP

Psoriatic Arthritis Response Criteria Response (coded 0=No, 1=Yes) is defined by improvement from baseline assessment in 2 of 4 criteria, 1 of which must be a joint count; there must not be worsening in any of the 4 criteria:

1. At least 30% reduction in tender joint grade (total of 68 joints graded 0-3)
2. At least 30% reduction in swollen joint grade (total of 66 joints graded 0-3)
3. At least a 1 point reduction in physician's assessment of articular disease (1-5 Likert scale)
4. At least a 1 point reduction in patient's assessment of articular disease (1-5 Likert scale)

Psoriatic Arthritis Response Criteria Response (coded 0=No, 1=Yes) is defined by improvement from baseline assessment in 2 of 4 criteria, 1 of which must be a joint count; there must not be worsening in any of the 4 criteria:

1. At least 30% reduction in tender joint grade (total of 68 joints graded 0-3)
2. At least 30% reduction in swollen joint grade (total of 66 joints graded 0-3)
3. At least a 1 point reduction in physician's assessment of articular disease (1-5 Likert scale)
4. At least a 1 point reduction in patient's assessment of articular disease (1-5 Likert scale)

Psoriatic Arthritis Response Criteria Response (coded 0=No, 1=Yes) is defined by improvement from baseline assessment in 2 of 4 criteria, 1 of which must be a joint count; there must not be worsening in any of the 4 criteria:

1. At least 30% reduction in tender joint grade (total of 68 joints graded 0-3)
2. At least 30% reduction in swollen joint grade (total of 66 joints graded 0-3)
3. At least a 1 point reduction in physician's assessment of articular disease (1-5 Likert scale)
4. At least a 1 point reduction in patient's assessment of articular disease (1-5 Likert scale)

Psoriatic Arthritis Response Criteria Response (coded 0=No, 1=Yes) is defined by improvement from baseline assessment in 2 of 4 criteria, 1 of which must be a joint count; there must not be worsening in any of the 4 criteria:

1. At least 30% reduction in tender joint grade (total of 68 joints graded 0-3)
2. At least 30% reduction in swollen joint grade (total of 66 joints graded 0-3)
3. At least a 1 point reduction in physician's assessment of articular disease (1-5 Likert scale)
4. At least a 1 point reduction in patient's assessment of articular disease (1-5 Likert scale)

Psoriatic Arthritis Skin Index (PASI) Response (coded 0=No, 1=Yes) is defined as an improvement of at least 75% in the PASI compared to baseline.

Psoriatic Arthritis Skin Index (PASI) Response (coded 0=No, 1=Yes) is defined as an improvement of at least 75% in the PASI compared to baseline.

Psoriatic Arthritis Skin Index (PASI) Response (coded 0=No, 1=Yes) is defined as an improvement of at least 75% in the PASI compared to baseline.

Psoriatic Arthritis Skin Index (PASI) Response (coded 0=No, 1=Yes) is defined as an improvement of at least 75% in the PASI compared to baseline.

Ultrasound Imaging Remission (coded 0=No, 1=Yes) is achieved when all joints and entheses score grey scale<=1 & power Doppler=0.

Ultrasound Imaging Remission (coded 0=No, 1=Yes) is achieved when all joints and entheses score grey scale<=1 & power Doppler=0.

Ultrasound Imaging Remission (coded 0=No, 1=Yes) is achieved when all joints and entheses score grey scale<=1 & power Doppler=0.

Participants were eligible for additional steroid at weeks 8 and 12 if they had not achieved a PsARC response; this variable was coded 0=No, 1=Yes.

Total of all reporting groups

The Psoriatic Arthritis Disease Activity Score (PASDAS) is a composite outcome based on the physician global VAS, participant global VAS, SF-36 physical component score, 66 swollen joint count, 68 tender joint count, Leeds enthesitis index, tender dactylitis count and C-reactive protein. The PASDAS ranges from 0-10, with higher values indicating higher disease activity.

The Leeds Enthesitis Index is a count of the number of tender entheses out of a possible 6 (lateral epicondyle, left and right, medial femoral condyle, left and right, Achilles tendon insertion, left and right). A higher score indicates a wider extent of enthesitis.

The Leeds Dactylitis Index measures dactylitis severity. The ratio of the circumference of the affected digit to the circumference of the digit on the opposite side is measured. Each dactylitic digit is defined by a minimum increase of 10% in circumference over the contra-lateral digit. The calculated ratio is then multiplied by a tenderness score of 0 (non-tender), 1 (tender), 2 (tender and wince) or 3 (tender and withdraw). Tenderness is assessed in the area between the joints. The results of each digit are then added to produce a total score. Range 0-~40, higher score means worse dactylitis

The PASI combines assessments of the extent of body-surface involvement in 4 anatomical regions (head, trunk, arms, and legs) and the severity of desquamation, erythema, and plaque induration/infiltration (thickness) in each region, yielding an overall score of 0 for no Pso to 72 for the most severe disease.

Each fingernail is scored for the presence and the severity of pitting, onycholysis, oil-drop dyschromia and nail plate crumbling (score 0-3) and the presence or absence of splinter haemorrhages, leuconychia, red spots in the lunula and nail bed hyperkeratosis (score 1 for each if present). The scale ranges from 0 to 140, higher scores indicate worse nail psoriasis.

Domains include peripheral arthritis (assessed by 68 tender joints count, 66 swollen joints count, and the Health Assessment Questionnaire), skin as assessed by the PASI and the DLQI, enthesitis as assessed by the number of sites with enthesitis and the HAQ, dactylitis as assessed by the number of digits affected, and spinal disease as assessed by the BASDAI and ASQoL. Scores range from 0 to 15. Higher scores indicate higher disease activity.

Joints are scored 0-3 for grey scale and power Doppler; a combined score takes a value of 0 if grey scale=0, if grey scale is >0 then the combined score is the maximum of the grey scale and power Doppler scores. Scores for individual joints are then summated to give a total global score. For the set of joints scanned in all participants, this ranges from 0-72; for the subset in whom a wider set of joints were scanned, this ranges from 0 to 144. Higher scores indicate worse synovial hypertrophy and vascularisation.

Grey scale changes in the entheses related to inflammation (entheseal hypoechogenicity and thickening) are added to power Doppler scores. The score ranges from 0-70, higher scores indicate worse entheseal inflammation.

Grey scale changes related to chronic findings (calcifications, erosion and enthesophytes) are summated. The score ranges from 0-50; higher scores indicate a greater extent of chronic entheseal pathology.

Participants are asked to assess their current level of joint pain by marking a vertical line on a 100 mm horizontal VAS where 0 represents no joint pain ("excellent") and 100 represents worst imaginable joint pain ("poor").

The DLQI is a simple, patient administered, 10 question, validated, quality of life questionnaire that covers 6 domains including symptoms and feelings, daily activities, leisure, work and school, personal relationships and treatment. Response categories include "not at all", "a lot" and "very much" with corresponding scores of 1, 2 and 3 respectively and unanswered ("not relevant") responses scored as "0". Totals range from 0 to 30 (less to more impairment) and a 5-point change from baseline is considered clinically relevant.

The SF-36 physical component summary scale ranges from 0-100, with scores above 50 indicating better than average physical health.

The SF-36 mental component summary scale ranges from 0-100, with scores above 50 indicating better than average mental health.

The Psoriatic Arthritis Disease Activity Score ranges from 0-10; higher scores represent a worse outcome.

Full analysis set

The Psoriatic Arthritis Disease Activity Score ranges from 0-10; higher scores represent a worse outcome.

Full analysis set

The Psoriatic Arthritis Disease Activity Score ranges from 0-10; higher scores represent a worse outcome.

Full analysis set

The Composite Psoriatic Disease Activity Index ranges from 0-15; higher scores represent a worse outcome.

Full analysis set

The Composite Psoriatic Disease Activity Index ranges from 0-15; higher scores represent a worse outcome.

Full analysis set

The Composite Psoriatic Disease Activity Index ranges from 0-15; higher scores represent a worse outcome.

Full analysis set

The Composite Psoriatic Disease Activity Index ranges from 0-15; higher scores represent a worse outcome.

Full analysis set

The Participant Disease Activity Visual Analogue Score ranges from 0-100; higher scores represent a worse outcome.

Full analysis set

The Participant Disease Activity Visual Analogue Score ranges from 0-100; higher scores represent a worse outcome.

Full analysis set

The 36-item Short Form Health Survey (SF-36) Physical Component Score ranges from 0-100; higher scores represent a better outcome.

Full analysis set

The 36-item Short Form Health Survey (SF-36) Physical Component Score ranges from 0-100; higher scores represent a better outcome.

Full analysis set

The 36-item Short Form Health Survey (SF-36) Mental Component Score ranges from 0-100; higher scores represent a better outcome.

Full analysis set

The 36-item Short Form Health Survey (SF-36) Mental Component Score ranges from 0-100; higher scores represent a better outcome.

Full analysis set

In the joint set scanned in the Full Analysis Set, the Ultrasound Global OMERACT-EULAR System Score ranged from 0-72; higher scores represent a worse outcome.

Full analysis set

In the joint set scanned in the Full Analysis Set, the Ultrasound Global OMERACT-EULAR System Score ranged from 0-72; higher scores represent a worse outcome.

Full analysis set

In the joint set scanned in the Full Analysis Set, the Ultrasound Global OMERACT-EULAR System Score ranged from 0-72; higher scores represent a worse outcome.

Full analysis set

The Ultrasound Entheseal Inflammatory Score ranged from 0-70; a higher score represents a worse outcome.

Full analysis set

The Ultrasound Entheseal Inflammatory Score ranged from 0-70; a higher score represents a worse outcome.

Full analysis set

The Ultrasound Entheseal Inflammatory Score ranged from 0-70; a higher score represents a worse outcome.

Full analysis set

The Ultrasound Entheseal Chronicity Score ranged from 0-50; a higher score represents a worse outcome.

Full analysis set

The Ultrasound Entheseal Chronicity Score ranged from 0-50; a higher score represents a worse outcome.

Full analysis set

The Ultrasound Entheseal Chronicity Score ranged from 0-50; a higher score represents a worse outcome.

Full analysis set