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| Name | Class |
|---|---|
| Cantonal Hospital of Graubünden, Chur, Switzerland | UNKNOWN |
| University Hospital, Geneva | OTHER |
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Processed electroencephalogram (EEG) monitors are routinely used in addition to clinical parameters to assess the depth of anaesthesia during general anaesthesia.
Processed electroencephalogram (EEG) monitors are routinely used in addition to clinical parameters to assess the depth of anaesthesia during general anaesthesia. In addition to the bispectral (BIS) index displayed as an index, the raw frontal EEG can be displayed as a curve on these monitors. After a short training, anaesthetists might be more accurate and faster in assessing depth of anaesthesia by recognizing the pattern of the EEG curve than by using the BIS index. This may further enhance the positive effects that could be demonstrated for the use of BIS monitors.
Therefore, the aim of the investigator's study is to investigate the clinical relevance of interpreting the raw frontal EEG in addition to only using the BIS index for titrating intravenous anaesthetics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention arm | Experimental | EEG monitoring in addition to standard monitoring (clinical parameters and BIS index) |
|
| Control arm | Active Comparator | Standard monitoring including clinical parameters and BIS index |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Training for EEG monitoring | Other | Training for reading EEG curves during anaesthesia |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Quality of recovery (QoR): QoR-15 scale | QoR-15 scale (scale from 0 to 150; 0 means best, 150 worst recovery) | 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Propofol consumption | Propofol consumption in mg/kg/h | during anaesthesia |
| Quality of recovery (QoR): QoR-15 scale | QoR-15 scale (scale from 0 to 150; 0 means best, 150 worst recovery) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Salome Dell-Kuster, MD MSc | University Hospital, Basel, Switzerland | Principal Investigator |
| Christoph S Burkhart, MD | Cantonal Hospital Graubünden | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cantonal Hospital Aarau | Aarau | Switzerland | ||||
| University Hospital Basel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35688587 | Derived | Gruber BU, Girsberger V, Kusstatscher L, Funk S, Luethy A, Jakus L, Maillard J, Steiner LA, Dell-Kuster S, Burkhart CS. Comparing propofol anaesthesia guided by Bispectral Index monitoring and frontal EEG wave analysis with standard monitoring in laparoscopic surgery: protocol for the 'EEG in General Anaesthesia - More Than Only a Bispectral Index' Trial, a multicentre, double-blind, randomised controlled trial. BMJ Open. 2022 Jun 10;12(6):e059919. doi: 10.1136/bmjopen-2021-059919. |
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Deidentified participant data will be available upon reasonable request from the last authors of this publication (Christoph S. Burkhart, ORCID 0000-0002-9288-117X and Salome Dell-Kuster, ORCID 0000-0001-7219-7138)
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| Standard monitoring |
| Other |
Standard monitoring including clinical parameters and BIS index |
|
| 48 hours after surgery |
| Time spent in postanaesthesia care unit (PACU) | Time in minutes from arrival in PACU until discharge from PACU | At arrival to and at discharge from postanaesthesia care unit (an average of 120 minutes) |
| Time to extubation | Time in minutes from skin closure to extubation | At time of skin closure and at time of extubation (an average of 90 minutes) |
| Risk of awareness | Brice interview daily until hospital discharge | daily from admission up to hospital discharge, an average of approximately 14 days |
| Aldrete score | Measurement of recovery; score is 0 to 10, 0 means worst recovery, 10 means best recovery | Once at discharge from postanaesthesia care unit (PACU), approximately on day 2 of admission to hospital |
| Incidence of Postoperative Nausea and Vomiting (PONV) | Incidence of nausea and vomiting daily until hospital discharge | daily from admission up to hospital discharge, an average of approximately 14 days |
| Basel |
| Switzerland |
| Cantonal Hospital Graubünden | Chur | Switzerland |
| Clinic of Anaesthesiology | Geneva | Switzerland |