This is a randomized controlled trail. A total of 28 individuals with aMCI will be randomly assigned to either the ISE group or control group. The ISE intervention conducts three times a week for 16 weeks. Outcomes are measured at baseline and after intervention. The primary outcomes are the Chinese version verbal learning test (CVVLT), selective reminding test (SRT), and logic memory test (Wechsler Memory Scale). The secondary outcomes are Montreal Cognitive Assessment (MoCA) for cognitive function, and trail making test Part A & B (TMT-A & B), Stroop test, and 25-item Executive Interview (C-EXIT 25) for executive function.

Inclusion Criteria:

• Age≥50 years
• Complained of memory impairment
• Chinese Version Verbal Learning Test 10-minute delays ≤ 6 words
• MMSE score≥24 and CDR score=0.5
• Activities of daily living are intact
• DSM-IV criteria for the diagnosis of dementia is not met

Exclusion Criteria:

• Any significant neurologic disease other than suspected incipient Alzheimer's disease
• Psychotic features, contraindication of exercise... which could lead to difficulty complying with the protocol