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Anemia is known as a condition in which the hemoglobin level is lower than normal. Anemia is one of the most common complications during pregnancy. Anemia in pregnancy is defined as a hemoglobin level < 110 g/L . Anemia is an important risk factor in pregnancy which leads to both maternal and fetal morbidity and mortality.
The pregnant woman needs more iron during pregnancy, so iron deficiency anemia is very common during pregnancy. In Egypt; iron deficiency anemia affects about one in every two pregnant women, especially in rural areas. Pregnant women require about 27 mg/day elemental iron to cover their increased need. The pregnant women should start taking a daily supplement of 30mg of elemental iron as a preventive measure against iron deficiency anemia especially in poor countries.
Obesity is defined as having an excessive amount of body fat. The body mass index, a measurement based on height and weight, determines the obese if the figure more than 30 kg/m2. There is an increased rate of overweight and obesity among pregnant women. According to the World Health Organization, 46% of adult females in Egypt are obese.
Many researches in the literature revealed a strong relationship between high BMI in pregnancy and iron deficiency anemia. Hepcidin is an iron regulating hormone in the body. Increases in iron levels in the plasma stimulate the production of hepcidin, which blocks iron absorption from the diet, so; hepcidin production is suppressed in the case of iron deficiency.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group I: 27 mg elemental iron | Active Comparator | will receive PharaFerro27; Devart Lab Company, Egypt; once daily starting at 12 -14 weeks until 37-38 weeks |
|
| Group II: 54 mg elemental iron | Active Comparator | will receive two tablets of PharaFerro27; Devart Lab Company, Egypt; daily starting at 12 -14 weeks until 37-38 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Iron | Drug | PharaFerro27; Devart Lab Company, Egypt |
|
| Measure | Description | Time Frame |
|---|---|---|
| The number of anemic women at time of delivery | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| The mean level of maternal Hemoglobin at 37-38 weeks . | 6 months | |
| The incidence of patients' reported side effect | 6 months | |
| The difference in serum ferritin |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Woman's Health Hospital - Assiut university | Asyut | 71111 | Egypt |
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| ID | Term |
|---|---|
| D007501 | Iron |
| D001772 | Blood Cell Count |
| ID | Term |
|---|---|
| D019216 | Metals, Heavy |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D028561 | Transition Elements |
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| Complete blood count | Diagnostic Test | to assess the anemia |
|
| Serum ferritin | Diagnostic Test | to assess the anemia |
|
| Serum hepcidin | Diagnostic Test | to assess the iron abosrption |
|
| Serum Iron | Diagnostic Test | to assess the anemia |
|
| Serum total iron binding capacity | Diagnostic Test | to assess the anemia |
|
| 6 months |
| The difference in serum hepcidin | 6 months |
| D008670 |
| Metals |
| D002452 | Cell Count |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006403 | Hematologic Tests |
| D008919 | Investigative Techniques |
| D002468 | Cell Physiological Phenomena |
| D001790 | Blood Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |