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Transcranial Direct Current Stimulation (tDCS), is a neuromodulatory technique, that is safe, well-tolerated, easy to administer and fairly inexpensive. Results from tDCS trials involving participants with several neuropsychiatric disorders, including major depression, bipolar disorder, schizophrenia and substance use disorder are encouraging. The clinical effects of tDCS are broad; the underlying condition, the areas stimulated together with the type and duration of stimulation are important factors. In patients with neuropsychiatric conditions, a reduction of symptoms, an enhancement of neurocognitive functions together with an overall improvement in functionality and wellbeing have been consistently reported. These effects emerge during the stimulation period, in the weeks after stimulation, the effects seem to peak and consolidate further. tDCS appears to enhance the effects of other interventions as well; however, to date, there have been no studies into the effects of using tDCS as an add-on intervention to psychotherapy on symptoms and wellbeing
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active tDCS | Experimental | Active tDCS will be delivered at 2mA for 20 minutes. |
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| Sham tDCS | Sham Comparator | Sham tDCS: after 40 seconds of stimulation (2mA), a small current pulse was delivered every 550 msec (110 muA over 15 msec). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Active tDCS | Device | Active tDCS will be delivered at 2mA for 20 minutes. |
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| Measure | Description | Time Frame |
|---|---|---|
| Psychopathological Assessment | Symptom Questionnaire | Change: Baseline, 3, 6 weeks, 6 and 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Insecurity- Self-confidence | Symptom Questionnaire | Change: Baseline, 3, 6 weeks, 6 and 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Stephan T. Egger, MD | Contact | +41523049340 | stephan.egger@puk.zh.ch |
| Name | Affiliation | Role |
|---|---|---|
| Stephan T. Egger, MD | Psychiatric University Hospital of Zurich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Psychiatrische Universitätsklinik Zürich | Recruiting | Zurich | 8032 | Switzerland |
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| ID | Term |
|---|---|
| D001523 | Mental Disorders |
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The investigators plan a double-blind, randomised, sham-controlled trial in a cross-over design to assess the efficacy and safety of tDCS as an add-on intervention to a psychotherapeutic treatment for patients with a severe psychiatric condition requiring hospitalization.
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| Assertiveness Training Program (ATP) | Behavioral | The Assertiveness Training Program (ATP) is a cognitive-behavioural therapy delivered in group sessions. |
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| Sham tDCS | Device | Sham tDCS, after 40 seconds of stimulation (2mA), a small current pulse was delivered every 550 msec (110 muA over 15 msec). |
|