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Randomized trial comparing the efficacy of two different times of administration of cabergoline in patients undergoing controlled ovarian stimulation and oocyte collection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Early administration | Experimental | Cabergoline administered the day before egg collection. |
|
| Late administration | Experimental | Cabergoline administered after egg collection. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cabergoline Pill | Drug | 0.5 mg cabergoline pill taken orally |
|
| Measure | Description | Time Frame |
|---|---|---|
| Discomfort level | Self-assessed discomfort level | 5 days after egg collection |
| Mature oocyte rate per follicular puncture | Ratio of mature oocytes obtained to punctured ovarian follicles | Within 24 hours of egg collection |
| Measure | Description | Time Frame |
|---|---|---|
| Ovarian volume | 5 days post retrieval | |
| oocyte count | Within 24 hours of egg collection | |
| Oocyte to follicle ratio |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bruce Shapiro, MD | Fertility Center of Las Vehas | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fertility Center of Las vegas | Las Vegas | Nevada | 89117 | United States |
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| ID | Term |
|---|---|
| D007247 | Infertility, Female |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D000077465 | Cabergoline |
| ID | Term |
|---|---|
| D004873 | Ergolines |
| D004876 | Ergot Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
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Laboratory personnel will not be informed of the subject's group assignment.
| Within 24 hours of egg collection |
| M1 oocyte rate | Within 24 hours of egg collection |
| M1 to M2 oocyte ratio | Within 24 hours of egg collection |
| Aneuploidy rate | Genetic test results of embryos for patients who opt for such testing. | Within 14 days of egg collection |
| D000091662 | Genital Diseases |
| D007246 | Infertility |
| D006576 |
| Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |