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The purpose of this study is to assess the effect of standard usual care combined with daily supervised physical training during hospitalization with community-acquired pneumonia (CAP) compared to standard usual care alnone.
Community-acuired pneumonia (CAP) is a leading cause of hospitalization worldwide. Despite increased focus on mobilization, hospitalization is associated with bed rest. Bed rest with low levels of physical activity leads to functional deline as well as increased risk of complications.
This study is a randomized controlled trial, which investigates the effect of standard usual care combined with daily supervised physical training in patients hospitalized with CAP compared to standard usual care alone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No intervention: Control | No Intervention | Control group | |
| In-bed cycling | Experimental | Supervised in-bed cycling |
|
| Exercise booklet | Experimental | Supervised physical training with exercises from exercise booklet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| In-bed cycling | Behavioral | Patients will daily perform 30 min of supervised in-bed cycling |
|
| Measure | Description | Time Frame |
|---|---|---|
| Length of hospital stay | Number of stays in hospital | From admission until discharge (an average of 5 days) |
| Measure | Description | Time Frame |
|---|---|---|
| Readmissions Number of readmissions | Time-to-event within 3-months from discharge | 3-months from discharge |
| Mortality | Time-to-event within 6-months from discharge |
| Measure | Description | Time Frame |
|---|---|---|
| Self-reported physical activity (PA) level | 3 groups of PA level (high, medium, low) are established based on the scoring of the international physical activity questionnaire (IPAQ).
|
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Camilla Ryrsø, MSc | Contact | +4548293261 | camilla.koch.ryrsoe.01@regionh.dk |
| Name | Affiliation | Role |
|---|---|---|
| Birgitte Lindegaard, MD, PhD | Department of Pulmonary and Infetious Diseases, Nordsjællands Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pulmonary and Infectious Diseases, Nordsjællands Hospital | Recruiting | Hillerød | 3400 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38491965 | Derived | Ryrso CK, Faurholt-Jepsen D, Ritz C, Hegelund MH, Dungu AM, Pedersen BK, Krogh-Madsen R, Lindegaard B. Effect of Exercise Training on Prognosis in Community-acquired Pneumonia: A Randomized Controlled Trial. Clin Infect Dis. 2024 Jun 14;78(6):1718-1726. doi: 10.1093/cid/ciae147. | |
| 34454594 | Derived | Ryrso CK, Faurholt-Jepsen D, Ritz C, Pedersen BK, Hegelund MH, Dungu AM, Sejdic A, Lindegaard B, Krogh-Madsen R. The impact of physical training on length of hospital stay and physical function in patients hospitalized with community-acquired pneumonia: protocol for a randomized controlled trial. Trials. 2021 Aug 28;22(1):571. doi: 10.1186/s13063-021-05503-2. |
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| ID | Term |
|---|---|
| D000098968 | Community-Acquired Pneumonia |
| ID | Term |
|---|---|
| D017714 | Community-Acquired Infections |
| D007239 | Infections |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
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| Exercise booklet | Behavioral | Patients will daily perform 30 min of supervised physical training with exercises from the exercise booklet |
|
| 6-months from discharge |
| Changes in total lean mass | Dual-energy x-ray absorptiometry scans | Day 1, day 5, discharge, 1- and 3-months from discharge |
| Changes in total fat mass | Dual-energy x-ray absorptiometry scans | Day 1, day 5, discharge, 1- and 3-months from discharge |
| Changes in total fat-free mass | Bioelectrical impedance analysis | Day 1, day 5, discharge, 1- and 3-months from discharge |
| Health-related quality of life | Scoring from -0.624 to 1.000 on the 5-level EQ-5D version (EQ-5D-5L) questionnaire (Danish version), with higher score indicating better health-related quality of life | Day 1, discharge, 1-, 3- and 6-months from discharge |
| Activities of daily living | Scoring from 0 to 100 on the Barthel Index for Activities of Daily Living (ADL) with higher score indicating greater independence. | Day 1, discharge, 1 month from discharge and 3 months from discharge |
| Muscle strength | Hand grip strength test | At day 1, day 5, discharge, 1- and 3-months after discharge |
| Functional ability | 30-sec chair stand test | Day 1, day 5, discharge, 1- and 3-months after discharge |
| Systemic inflammation | Pro- and anti-inflammatory cytokine concentrations measured in pg/ml (IL-6, IL-8, IL-18, IL-1a, IL-10, TNF-alpha) | Daily during admission (day 0 to 5), 1- and 3-months after discharge |
| Physical activity monitoring | AX3 accelerometers | During admission (up to 7 days), 7 days from discharge, 7 days from 1- and 3 months follow-up |
| Answered on day 1, 1-, 3- and 6 months after discharge |
| Glucose metabolism | Blood samples drawn during an oral glucose tolerance test | Day 1, 1- and 3-months from discharge |
| Scoring on the Charlson Comorbidity Index to predict 10-year survival | Scale ranges from 0 to 33 points to predict he 10-year mortality for patients with a range of comorbid conditions | Day 1 |
| HbA1c | To assess the average blood glucose levels over the previous 3 months | Day 1, 1- and 3-months after discharge |
| D012140 |
| Respiratory Tract Diseases |