Endocrinological Profile in Patients With Medication-overuse Headache Before and After Withdrawal Therapy

Endocrinological Profile in Patients With Medication-overuse Headache Before

The project will be conducted to investigate the hormonal homeostasis in men and women, with a special emphasis on sex hormones in men and AMH level in women, before and after withdrawal of the overused analgesics among MOH patients. Additionally, a more broad endocrine profile will be explored before and after withdrawal.

It is hypothesized that patients with MOH have disturbed hormone levels, which is normalized after withdrawal of the medication-overuse.

Inclusion Criteria:

• Confirmed MOH diagnosis according to the ICHD-III (1).
• Capable of completing headache diary and headache calendar
• Age 18-60 years old for men and 18-50 years old for women
• Signed informed consent
• BMI 19-30

Exclusion Criteria:

• Severe physical illness
• Severe psychiatric disorders requiring pharmacological treatment
• Addiction to alcohol or other drugs
• Pregnancy or breastfeeding
• Menopause, either natural or surgical (only women)
• Inability to provide reliable information about medical history