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| ID | Type | Description | Link |
|---|---|---|---|
| APHP180561 | Other Identifier | AP-HP | |
| 2019-A01226-51 | Other Identifier | IDRCB |
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| Name | Class |
|---|---|
| Direction Générale de l'Offre de Soins | OTHER_GOV |
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The aim of this study is to identify in hospitalized patients, the risk factors associated with the digestive colonisation by emergent extensively drug-resistant bacteria (eXDR), to optimize their detection and the medical care for carriers these patients
CODBAHRE is a french, regional study, involving 9 centers. Recruitment will take place in all the departments of the centers involved under the supervision of the Infection Control Team.
All patients hospitalized more than 24 hours, on a given day are eligible for the protocol, except the patients unable to answer the questionnaire.
After collecting the non-opposition of the patient, patients will be screened by rectal swab and a questionnaire will be completed.
Each sample will be analyzed to detect eXDR carrying patients.
The carrying patients will be followed during 6 months to estimate the proportion of the population which developped a bacterial infection. This information will be collected by a retrospective telephone survey of carrying patients.
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| Measure | Description | Time Frame |
|---|---|---|
| Risk factors | Identification of risk factors for digestive colonisation by highly resistant bacteria Lifestyle questionnaire: environment, diet, medical history and result of the rectal swab | at inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of multidrug-resistant bacteria will be determined by the number of patients who have been detected at least one multidrug-resistant bacteria referred to the number of patients sampled | Number of patient carrying a Multidrug-resistant bacteria in Ile de France | 1 day |
| Prevalence of co-carrying patients of eXDR and ESBL will be determined by the number of patients who carrying eXDR and ESBL referred to the number of patients sampled |
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Inclusion Criteria:
Exclusion Criteria:
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Any patient hospitalized more than 24 hours, on a given day in one of the participating hospitals, is eligible to be included in the protocol, unless hospitalized in psychiatry
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| Name | Affiliation | Role |
|---|---|---|
| Najiby Kassis-Chikhani, PhD | AP-HP, Hôpital Européen Georges Pompidou, Paris | Principal Investigator |
| Jean-Ralph Zahar, PhD | AP-HP, Hôpitaux Avicenne, Jean Verdier, et René Muret, Bobigny | Principal Investigator |
| Véronique Moulin | AP-HP, Hôpital Corentin Celton, et Vaugirard | Principal Investigator |
| Pierre Frange, PhD | AP-HP, Hôpital Necker enfants malades, Paris | Principal Investigator |
| Christine Lawrence, PhD | AP-HP, Hôpital Raymond Poincaré, Garches | Principal Investigator |
| Frédéric Barbut, PhD | AP-HP-Hôpital Saint Antoine, Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| HEGP | Paris | France |
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one year after the last publication
Data sharing must be accepted by the sponsor and the PI based on scientific project and scientific involvement of the PI team.
Teams wishing obtain IPD must meet the sponsor and IP team to present scientifics (and commercial) purpose, IPD needed, format of data transmission, and timeframe. Technical feasibility and financial support will be discussed before mandatory contractualization
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Rectal swab
Estimate the prevalence of "co-carrying patients of eXDR and ESBL in the Ile de France |
| 1 day |
| Prevalence will be determined by the number of patients who carrying at least one Multidrug-resistant bacteria referred to the number of patients sampled | Establish whether there are significant differences between hospital associated with the recruitment of these institutions. | 1 day |
| Proportion of patients carrying "eXDR" who will develop an infection with the same germ referred to the number of eXDR carriers | Estimate the proportion of patients colonized by a "eXDR" who will develop an infection with the same germ. | 6 months |
| Cross-transmission rate of eXDR | Number of cross transmissions during the study by comparing the eXDR bacteria genotypes in the same unit | 1 day |
| Description of the association between strains (RAPD, infrared Biotyper, genome sequencing). | Identify possible links between strains | 16 months |
| Description of resistance and virulence characteristics between strains (RAPD, infrared Biotyper, genome sequencing). | Characterize the resistance and virulence factors of certain strains. | 16 months |
| Comparison of the frequency of positive presence of eXDR bacteria obtained between culture technic and molecular biology technic | Comparison culture vs molecular biology technics. | 16 months |