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The plasma level of mtDNA in sepsis is affected by continous venovenous hemofiltation（CVVH）
Continous renal replacement therapy （CRRT）has become routine for patients with chronic renal failure ，AKI，fliud overload as well as oliguria in ICU .In clinical patients ，continous venovenous hemofoiltration （CVVH）is actually the method of chioce for CRRT in critically ill and hemodynamic instable patients .CVVH has significant beneficial effects on removing inflammatory cytokines ，improving oxygen index，increasing cardiac index and regulating immune dysfuntion .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Septic patients require CVVH | Experimental | continuous venovenous hemofiltration. Continuous renal replacement therapy（CRRT）has become routine for patients with chronic renal failure ，AKI，fliud overload as well as oliguria in ICU .Continuous venovenous hemofiltration（CVVH）is the method of chioce for CRRT in critical ill .CVVH has significant beneficial effects on removing inflammatory cytokines ，improving oxygen index ，decreasing vasopressor requirements，increasing cardiac index and regulating immune dysfunction . |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| continous venovenous hemofiltraion | Procedure | CVVH |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of mtDNA concentration in plasma | The specimens in the prefilter and postfilter blood as well as in the ultrafiltrate were obtained at the beginning of CRRT (T0) and 6 h (T6h), 12 h (T12h) after the setup of CVVH. | befor,6hours, 12hours, after CVVH treatment |
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Inclusion Criteria:
Adult septic patients undergoing CRRT
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| dixian luo, MS | Chenzhou First people Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Hospital of Chenzhou | Chenzhou | Hunan | 450003 | China |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |