Cytotoxicity of Yellow Fever Specific CD8 T Cells Following YF-17D Vaccination

Cytotoxicity of Yellow Fever Specific CD8 T Cells Following YF-17D Vaccination

Investigating cytotoxicity of yellow fever specific CD8 T cells following YF-17D vaccination and the following licensing of these epitope-specific CD8 T cells

CD: cluster of differentiation YF: yellow fever

Inclusion Criteria:

• Age between 18 to 60 years
• Informed consent given

Exclusion Criteria:

• Fever (orally >37,5 C) on day of vaccination
• Immunosuppressants
• Pregnant or breast feeding
• Severe immunodeficiency
• Known thymus dysfunction
• Allergy against egg
• Known haemophilia
• Previous severe reaction to vaccine
• Not willing to use anticonceptives 4 weeks after vaccination