Epigenetic Biomarkers for Alzheimer's Disease

Identification of Epigenetic Biomarkers for Alzheimer's Disease in Blood Using Epigenome-wide Analysis

Alzheimer's disease (AD) is a neurodegenerative disorder with no know cure. The pathogenesis of late onset AD (LOAD) is complex and multifactorial in nature, with multiple susceptibility genes and environmental factors at interplay.

The objective of this study is to improve our understanding of the risk factors of LOAD by conducting an epigenome wide study within patients of LOAD contrasted against their cognitively normal siblings.

Inclusion Criteria:

• Sufficient Cantonese competency for cognitive test
• Written informed consent given
• Have at least one gender-matched cognitively normal sibling

Exclusion Criteria:

• Subjects who refuse blood taking procedure
• Do not have a reliable family/caregiver informant (personal contact at least once a month)