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Sleep-disordered breathing has a prevalence of 30~80% in patients with heart diseases. Various studies have revealed a correlation between the incidence and various diseases such as heart failure, hypertension, diabetes, and cerebral infarction. Postoperative acute kidney injury after heart surgery is one of the major complications with incidence with 40~50%, however, there has been no preventive method or treatment yet. Recently, several studies have been published that have shown a correlation between sleep-disordered breathing and renal impairment. In general, sleep-disordered breathing can be regulated easily with continues positive expiratory pressure, which means that early diagnosis and treatment of sleep-disordered breathing might help to reduce the incidence of postoperative acute kidney injury and improve patients' prognosis.
In this study, the investigators investigate the impact of sleep-disordered breathing (diagnosed by oxygen desaturation index ≥5) on the incidence of postoperative acute kidney injury in patients undergoing valvular heart surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal | Patients with Oxygen desaturation index <5 | ||
| Sleep-disordered breathing | Patients with Oxygen desaturation index ≥5 |
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| Measure | Description | Time Frame |
|---|---|---|
| Postoperative acute kidney injury | Postoperative acute kidney injury development defined by KDIGO criteria for postoperative 7 days. -KDIGO(Kidney Disease Improving Global Outcomes) is the global nonprofit organization developing and implementing evidence-based clinical practice guidelines in kidney disease. | Postoperative 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Urinary NGAL(Neutrophil gelatinase-associated lipocalin) by ELISA(enzyme-linked immunosorbent assay) | Urinary NGAL measurement by ELISA after anesthetic induction | 15 minutes after anesthetic induction |
| Urinary NGAL(Neutrophil gelatinase-associated lipocalin) by ELISA(enzyme-linked immunosorbent assay) |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients undergoing valvular heart surgery
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Pain Medicine, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine | Recruiting | Seoul | 03722 | South Korea |
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| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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The investigators measure the urinary NGAL.
Urinary NGAL measurement by ELISA after 6hours after cardiopulmonary bypass discontinuation |
| Post-CPB 6hours |
| Urinary NGAL(Neutrophil gelatinase-associated lipocalin) by ELISA(enzyme-linked immunosorbent assay) | Urinary NGAL measurement by ELISA after 24hours after cardiopulmonary bypass discontinuation | Post-CPB 24hours |